Plachý J, Karakoz I, Benda V
Institute of Molecular Genetics, Czechoslovak Academy of Sciences, Praha.
Folia Biol (Praha). 1986;32(5):334-48.
We report results on the age-dependent effect of the B (MHC) genotype on resistance to the growth of a second RSV tumour in chickens from highly inbred lines genetically resistant or susceptible to progressive growth of primary RSV-induced tumours. Furthermore, the second inoculation of RSV caused either accelerated or retarded growth of the primary tumours induced by the same virus. These two types of response to a second challenge with RSV were controlled by alleles of the chicken major histocompatibility (B) complex. The retarded growth of the primary tumours was found to be thymus-dependent. Furthermore, a clear-cut trans-complementation effect of two B alleles on the response to RSV challenge was demonstrated.
我们报告了关于B（MHC）基因型对来自高度近交系的鸡抵抗第二种劳斯肉瘤病毒（RSV）肿瘤生长的年龄依赖性影响的研究结果，这些近交系对原发性RSV诱导肿瘤的渐进性生长具有遗传抗性或易感性。此外，第二次接种RSV会导致由同一病毒诱导的原发性肿瘤加速或延缓生长。对RSV第二次攻击的这两种反应类型由鸡主要组织相容性（B）复合体的等位基因控制。原发性肿瘤的生长延缓被发现依赖于胸腺。此外，还证明了两个B等位基因对RSV攻击反应的明显反式互补效应。
