Wisner T W, England J M, Pan D Y, Stoker A W, Halpern M S
Wistar Institute of Anatomy and Biology, Philadelphia, Pennsylvania 19104.
J Virol. 1991 Dec;65(12):7020-4. doi: 10.1128/JVI.65.12.7020-7024.1991.
Previous studies have indicated that the regression versus progression of v-src-DNA-induced sarcomas is dependent on chicken line. As a first step in analyzing the role of tumor immunity as a determinant of this line dependence, experiments were undertaken to ascertain whether an antisarcoma immune response is generated in the course of sarcoma growth in TK chickens, a regressor line. To assay for this response, test TK chickens in which v-src-induced wing web sarcomas had regressed, as well as control TK chickens that had not been exposed to v-src, were challenged in protocols known to yield v-src-dependent sarcoma formation and monitored for challenge sarcoma growth. Compared with the control chickens, the test chickens showed a significant resistance to the sarcomagenic challenge. These results raise the possibility that the antisarcoma response that is inducible in regressor lines, as demonstrated here in terms of a protective effect against a subsequent sarcomagenic challenge, may also underlie the regression of v-src-induced primary sarcomas.
先前的研究表明，v-src-DNA诱导的肉瘤的消退与进展取决于鸡的品系。作为分析肿瘤免疫作为这种品系依赖性决定因素的作用的第一步，开展了实验以确定在TK鸡（一种消退型品系）的肉瘤生长过程中是否会产生抗肉瘤免疫反应。为了检测这种反应，对v-src诱导的翼蹼肉瘤已经消退的受试TK鸡以及未接触过v-src的对照TK鸡，按照已知能产生v-src依赖性肉瘤形成的方案进行攻击，并监测攻击后肉瘤的生长情况。与对照鸡相比，受试鸡对致肉瘤攻击表现出显著的抗性。这些结果增加了一种可能性，即在此处就针对后续致肉瘤攻击的保护作用而言，在消退型品系中可诱导的抗肉瘤反应，可能也是v-src诱导的原发性肉瘤消退的基础。
