急性肿瘤病毒与地塞米松对人皮肤成纤维细胞的转化/新分化作用
Transformation/neodifferentiation of human skin fibroblasts by acute oncornaviruses and dexamethasone.
作者信息
Kopelovich L, Fenyk J
机构信息
Laboratory of Cancer Genetics and Cancer Prevention, VA Medical Center, Bay Pines, Fla.
出版信息
Exp Cell Biol. 1988;56(6):311-20. doi: 10.1159/000163497.
We demonstrated that the Kirsten murine sarcoma virus (KiMSV) and the Harvey murine sarcoma virus (HaMSV) converted human skin fibroblasts (HSF) into adipocytes. Adipocytic conversion of HSF by KiMSV and HaMSV was dependent on the presence of glucocorticosteroids. The Kirsten murine leukemia virus, the Harvey murine sarcoma [corrected] virus and the amphotropic helper virus (AP292) were ineffective by themselves. Balb murine sarcoma virus and Moloney murine sarcoma virus were, to a lesser degree, able to effect adipocytic conversion of HSF. In contrast, the feline sarcoma virus and the simian sarcoma virus did not cause this conversion. Together, the results suggest a role for certain oncogenes and glucocorticosteroids in the transformation/neodifferentiation of human cells.
我们证明，柯斯顿鼠肉瘤病毒（KiMSV）和哈维鼠肉瘤病毒（HaMSV）可将人皮肤成纤维细胞（HSF）转化为脂肪细胞。KiMSV和HaMSV介导的HSF脂肪细胞转化依赖于糖皮质激素的存在。柯斯顿鼠白血病病毒、哈维鼠肉瘤病毒（已修正）和双嗜性辅助病毒（AP292）单独作用时无效。巴尔b鼠肉瘤病毒和莫洛尼鼠肉瘤病毒在较小程度上能够实现HSF的脂肪细胞转化。相比之下，猫肉瘤病毒和猿猴肉瘤病毒不会引起这种转化。总之，这些结果表明某些癌基因和糖皮质激素在人类细胞的转化/新分化中发挥作用。
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