Salas Juan M, Caballero Ana B, Esteban-Parra Ginés M, Méndez-Arriaga José M
Department of Inorganic Chemistry, University of Granada, Avda. Severo Ochoa s/n, 18071 Granada. Spain.
Department of Inorganic and Organic Chemistry (Inorganic Chemistry Section), University of Barcelona, Martí i Franquès 1-11, 08028 Barcelona. Spain.
Curr Med Chem. 2017;24(25):2796-2806. doi: 10.2174/0929867324666170516122024.
Since their first synthesis back in the early 20th century, 1,2,4-triazolo[1,5- a]pyrimidines have aroused increasing interest in very diverse areas ranging from chemotherapy to agriculture or even photography. Their similarity to purines confers a potential bioactivity and this feature has been wisely exploited for therapeutic use, including antifungal, antipyretic, analgesic, antiinflammatory, antitumoral and antiparasitic properties. In this review, we focus on the compounds that these nitrogen heterocycles form with metal ions and their antiparasitic activity and therapeutic potential against two neglected diseases of tropical prevalence, leishmaniasis and Chagas disease.
自20世纪初首次合成以来，1,2,4-三唑并[1,5-a]嘧啶在从化疗到农业甚至摄影等非常广泛的领域引起了越来越多的关注。它们与嘌呤的相似性赋予了潜在的生物活性，并且这一特性已被明智地用于治疗用途，包括抗真菌、解热、镇痛、抗炎、抗肿瘤和抗寄生虫特性。在本综述中，我们重点关注这些氮杂环与金属离子形成的化合物及其对两种热带流行的被忽视疾病——利什曼病和恰加斯病的抗寄生虫活性和治疗潜力。
