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从必需元素到抗寄生虫治疗剂的锌。

Zinc from an Essential Element to an Antiparasitic Therapeutic Agent.

作者信息

Navarro Maribel, Daniel Luana Vanessa, Colina-Vegas Legna, Visbal Gonzalo

机构信息

Laboratório de Químicas Bioinorgânica e Catalise (LaQBIC), Departamento de Química, Instituto de Ciências Exatas, Universidade Federal de Juiz de Fora Juiz de Fora, Juiz de Fora 36036-900, Brazil.

Instituto de Química, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre 91501-970, Brazil.

出版信息

ACS Omega. 2025 Jan 17;10(3):2393-2414. doi: 10.1021/acsomega.4c07331. eCollection 2025 Jan 28.

DOI:10.1021/acsomega.4c07331
PMID:39895759
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11780429/
Abstract

Tropical parasitic diseases affect millions of people around the world, particularly in poor countries. The human parasitic diseases that will be covered in this review are malaria and neglected diseases, such as leishmaniasis, Chagas disease, and African trypanosomiasis. The current treatments for these diseases present several problems, such as the development of drug resistance, very limited drugs available in the clinic, significant side effects of the drugs, and a long treatment period. For these reasons, there is an urgent need to develop new chemotherapeutics to eradicate or eliminate these diseases. Zinc-based drugs against parasitic diseases could be an alternative therapy to overcome the difficulties of the approved metallodrugs as antiparasitic agents. Zinc-based drugs are becoming an exciting field of research because zinc is an essential element that can lead to the development of multitarget antiparasitic agents, which are reviewed here.

摘要

热带寄生虫病影响着全球数百万人，尤其是在贫穷国家。本综述将涵盖的人类寄生虫病包括疟疾以及一些被忽视的疾病，如利什曼病、恰加斯病和非洲锥虫病。目前针对这些疾病的治疗方法存在若干问题，例如耐药性的产生、临床可用药物非常有限、药物副作用严重以及治疗周期长。由于这些原因，迫切需要开发新的化学疗法来根除或消除这些疾病。针对寄生虫病的锌基药物可能是一种替代疗法，以克服已获批的金属药物作为抗寄生虫剂所面临的困难。锌基药物正成为一个令人兴奋的研究领域，因为锌是一种必需元素，可促使开发多靶点抗寄生虫剂，本文将对此进行综述。

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本文引用的文献

1
Metal(triphenylphosphine)-atovaquone Complexes: Synthesis, Antimalarial Activity, and Suppression of Heme Detoxification.金属（三苯基膦）-阿托伐醌配合物：合成、抗疟活性及对血红素解毒的抑制作用
Inorg Chem. 2024 Sep 16;63(37):17087-17099. doi: 10.1021/acs.inorgchem.4c02751. Epub 2024 Aug 26.
2
The End Justifies the Means: Chagas Disease from a Perspective of the Host- Interaction.不择手段，后果论之：从宿主相互作用角度看恰加斯病
Life (Basel). 2024 Apr 9;14(4):488. doi: 10.3390/life14040488.
3
Metallomics: An Essential Tool for the Study of Potential Antiparasitic Metallodrugs.
金属组学：研究潜在抗寄生虫金属药物的重要工具。
ACS Omega. 2024 Mar 25;9(14):15744-15752. doi: 10.1021/acsomega.3c10200. eCollection 2024 Apr 9.
4
First-Row Transition 7-Oxo-5-phenyl-1,2,4-triazolo[1,5-a]pyrimidine Metal Complexes: Antiparasitic Activity and Release Studies.第一排过渡元素7-氧代-5-苯基-1,2,4-三唑并[1,5-a]嘧啶金属配合物：抗寄生虫活性及释放研究
Pharmaceuticals (Basel). 2023 Sep 28;16(10):1380. doi: 10.3390/ph16101380.
5
Tackling Sleeping Sickness: Current and Promising Therapeutics and Treatment Strategies. tackling 昏睡病：当前和有前途的治疗方法和治疗策略。
Int J Mol Sci. 2023 Aug 7;24(15):12529. doi: 10.3390/ijms241512529.
6
Effects of Daily Zinc Alone or in Combination with Other Nutrient Supplements on the Risk of Malaria Parasitaemia: A Systematic Review and Meta-Analysis of Randomised Controlled Trials.单独或联合其他营养补充剂补充锌对疟疾寄生虫血症风险的影响：随机对照试验的系统评价和荟萃分析。
Nutrients. 2023 Jun 23;15(13):2855. doi: 10.3390/nu15132855.
7
Recent Advances in Chemotherapeutics for Leishmaniasis: Importance of the Cellular Biochemistry of the Parasite and Its Molecular Interaction with the Host.利什曼病化疗药物的最新进展：寄生虫细胞生物化学及其与宿主分子相互作用的重要性
Pathogens. 2023 May 12;12(5):706. doi: 10.3390/pathogens12050706.
8
Zinc(II)-Sterol Hydrazone Complex as a Potent Anti- Agent: Synthesis, Characterization, and Insight into Its Mechanism of Antiparasitic Action.锌（II）-甾醇腙配合物作为一种有效的抗寄生虫剂：合成、表征及其抗寄生虫作用机制的深入研究。
Pharmaceutics. 2023 Mar 31;15(4):1113. doi: 10.3390/pharmaceutics15041113.
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Overcoming insecticide resistance in Anopheles mosquitoes by using faster-acting solid forms of deltamethrin.通过使用作用更快的氯菊酯固态形式来克服疟蚊的抗药性。
Malar J. 2023 Apr 21;22(1):129. doi: 10.1186/s12936-023-04554-x.
10
Zinc: From Biological Functions to Therapeutic Potential.锌：从生物学功能到治疗潜力。
Int J Mol Sci. 2023 Mar 2;24(5):4822. doi: 10.3390/ijms24054822.