快速眼动睡眠期间的脑灌注可成功识别遗忘型轻度认知障碍。
Brain perfusion during rapid-eye-movement sleep successfully identifies amnestic mild cognitive impairment.
作者信息
Brayet Pauline, Petit Dominique, Baril Andrée-Ann, Gosselin Nadia, Gagnon Jean-François, Soucy Jean-Paul, Gauthier Serge, Kergoat Marie-Jeanne, Carrier Julie, Rouleau Isabelle, Montplaisir Jacques
机构信息
Department of Psychology, Université du Québec à Montréal, Montréal, Canada; Center for Advanced Research in Sleep Medicine, Hôpital du Sacré-Coeur de Montréal, Montréal, Canada.
Center for Advanced Research in Sleep Medicine, Hôpital du Sacré-Coeur de Montréal, Montréal, Canada.
出版信息
Sleep Med. 2017 Jun;34:134-140. doi: 10.1016/j.sleep.2017.01.025. Epub 2017 Mar 30.
INTRODUCTION
Prodromal markers of Alzheimer's disease (AD) have been derived from wakefulness. However, brain perfusion during rapid-eye movement (REM) sleep could be a sensitive marker of amnestic mild cognitive impairment (aMCI), as activation of REM sleep relies more on the cholinergic system.
METHODS
Eight subjects with aMCI, and 16 controls, underwent two single-photon emission computed tomography (SPECT) scans with tracer injected during REM sleep then wakefulness.
RESULTS
Perfusion in the anterior cingulate cortex was significantly decreased in aMCI cases compared to controls for both conditions. That defect was much larger and more severe in REM sleep (1795 voxels) compared to wakefulness (398 voxels), and extended to the middle cingulate cortex and the olfactory cortex. Hypoperfusion in the anterior cingulate cortex during REM sleep allowed better classification than hypoperfusion found in wakefulness (93.8 vs 81.3%).
CONCLUSION
REM sleep imaging is a valuable tool with which to identify individuals at risk of developing AD.
引言
阿尔茨海默病（AD）的前驱标志物源自清醒状态。然而，快速眼动（REM）睡眠期间的脑灌注可能是遗忘型轻度认知障碍（aMCI）的敏感标志物，因为REM睡眠的激活更多依赖胆碱能系统。
方法
8名aMCI患者和16名对照者接受了两次单光子发射计算机断层扫描（SPECT），分别在REM睡眠和清醒状态下注射示踪剂。
结果
与对照者相比，aMCI患者在两种状态下前扣带回皮质的灌注均显著降低。与清醒状态（398个体素）相比，REM睡眠时该缺陷更大且更严重（1795个体素），并扩展至中扣带回皮质和嗅觉皮质。REM睡眠期间前扣带回皮质的灌注不足比清醒状态下的灌注不足具有更好的分类效果（93.8%对81.3%）。
结论
REM睡眠成像对于识别有患AD风险的个体是一种有价值的工具。
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