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干扰素α-2a作为结膜鳞状细胞癌的替代治疗方法。

Interferon alpha-2a as alternative treatment for conjunctival squamous cell carcinoma.

作者信息

Cruzado-Sánchez D, Salas-Diaz M, Tellez W A, Alvarez-Matos S E, Serpa-Frías S

机构信息

Servicio de Oftalmología Oncológica, Departamento de Cabeza y Cuello, Instituto Nacional de Enfermedades Neoplásicas (INEN), Perú.

Universidad Nacional Federico Villarreal, Perú.

出版信息

Arch Soc Esp Oftalmol. 2017 Nov;92(11):539-542. doi: 10.1016/j.oftal.2017.03.006. Epub 2017 May 15.

DOI:10.1016/j.oftal.2017.03.006
PMID:28522115
Abstract

CASE REPORT

A 35 year-old male patient with a history of HIV infection characterized by progressive tumour growth in bulbar conjunctiva of the left eye, corresponding to conjunctival squamous cell carcinoma that responded to treatment with interferon alpha-2a.

DISCUSSION

Interferon alpha-2b has been used at conjunctival level as a topical immunomodulator treatment, with complete remission of epithelial neoplasms being observed. However, there have not been any previous publications on the use of interferon alpha-2a, which differs from interferon alpha-2b in a single amino acid, for the treatment of conjunctival squamous cell carcinoma.

摘要

病例报告

一名35岁男性患者,有HIV感染史,其特征为左眼球结膜肿瘤进行性生长,诊断为结膜鳞状细胞癌,对α-2a干扰素治疗有反应。

讨论

α-2b干扰素已被用作结膜局部免疫调节剂治疗,观察到上皮肿瘤完全缓解。然而,此前尚无关于使用α-2a干扰素治疗结膜鳞状细胞癌的报道,α-2a干扰素与α-2b干扰素仅在一个氨基酸上不同。

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Interferon alpha-2a as alternative treatment for conjunctival squamous cell carcinoma.干扰素α-2a作为结膜鳞状细胞癌的替代治疗方法。
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[Conjunctival squamous cell carcinoma: paradoxical response to interferon eyedrops].[结膜鳞状细胞癌:对干扰素滴眼液的矛盾反应]
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