Huerva V, Mangues I
Ophthalmology Department, University Hospital Arnau de Vilanova, Lleida, Spain.
J Fr Ophtalmol. 2008 Mar;31(3):317-25. doi: 10.1016/s0181-5512(08)74813-7.
The classical approach to the treatment of squamous neoplasias of the ocular surface is based on surgical resection and cryotherapy. High rates of recurrence have been demonstrated if the margins are not free after the resection. Primary or adjuvant chemotherapy with mitomycin C (MMC) or 5-fluorouracil has been employed to treat these neoplasias, but severe side effects on the ocular surface have been described. Interferon (INF) alpha 2b is less toxic to the ocular surface. The experience in the treatment of conjunctiva-cornea intraepithelial neoplasia (CIN) with topical or intralesional INF alpha 2b is based on isolated cases or very short series. In this report, we review the published studies and include our personal experience. The safety and effectiveness of INF alpha 2b in the treatment of primary and recurrent cases of CIN are described. The absence of serious side effects after topical administration of INF alpha 2b leads to the recommendation of this modality of therapy for primary and recurrent cases of CIN.
眼表鳞状上皮肿瘤的经典治疗方法是手术切除和冷冻疗法。如果切除后切缘不净，复发率会很高。已采用丝裂霉素C（MMC）或5-氟尿嘧啶进行原发性或辅助化疗来治疗这些肿瘤，但已报道对眼表有严重副作用。干扰素（INF）α2b对眼表的毒性较小。局部或病灶内注射INFα2b治疗结膜-角膜上皮内瘤（CIN）的经验基于个别病例或非常短的系列研究。在本报告中，我们回顾了已发表的研究并纳入了我们的个人经验。描述了INFα2b治疗原发性和复发性CIN病例的安全性和有效性。局部应用INFα2b后无严重副作用，因此推荐将这种治疗方式用于原发性和复发性CIN病例。
