一次抑制一个蛋白质的翻译。
Inhibiting Translation One Protein at a Time.
机构信息
Department of Chemistry, The Scripps Research Institute, Jupiter, FL 33458.
出版信息
Trends Biochem Sci. 2017 Jun;42(6):412-413. doi: 10.1016/j.tibs.2017.04.008. Epub 2017 May 15.
PMID:28522328
Abstract
Historically, translational inhibitors have been confined to anti-bacterials that globally affect translation. Lintner et al. demonstrate that small molecules can specifically inhibit translation of a single disease-associated protein by stalling the ribosome's nascent chain [1], opening up a new therapeutic strategy for 'undruggable' proteins.
摘要
从历史上看，翻译抑制剂一直局限于全球影响翻译的抗细菌药物。Lintner 等人证明，小分子可以通过使核糖体的新生链停滞来特异性抑制单个与疾病相关的蛋白质的翻译[1]，为“不可成药”的蛋白质开辟了新的治疗策略。
Zotero 插件