Golden D L, Lothrop C D
Department of Urban Practice, College of Veterinary Medicine, University of Tennessee, Knoxville 37901.
J Vet Intern Med. 1988 Jul-Sep;2(3):121-5. doi: 10.1111/j.1939-1676.1988.tb02807.x.
A retrospective study on stored plasma from normal dogs and dogs with pituitary dependent hyperadrenocorticism (PDH), pituitary dependent hyperadrenocorticism controlled by mitotane (o,p'-DDD),* iatrogenic hyperadrenocorticism, and hypoadrenocorticism was conducted to determine if alterations in aldosterone production exist in these disorders. The plasma aldosterone concentration (PAC) was measured by radioimmunoassay immediately before and 1 hour after adrenocorticotropic hormone (ACTH) administration (0.5 IU/kg, intravenously [IV]). PACs increased significantly when ACTH was administered to normal dogs. Dogs with PDH had a lower baseline PAC, but their PAC increased to levels similar to that of normal dogs after ACTH administration. In dogs with PDH controlled by o,p'-DDD therapy, the response to ACTH was significantly less than that of normal dogs or dogs with untreated PDH. Dogs with iatrogenic hyperadrenocorticism had a lower baseline and post-ACTH PAC than normal dogs. Dogs with hypoadrenocorticism had a normal basal PAC, but showed no significant increase in PAC following ACTH administration. These findings suggest that PACs are significantly altered in a variety of adrenal diseases, and that the ACTH stimulation test may be useful when evaluating aldosterone secretion in adrenopathic disorders. In addition, at therapeutic dosages, o,p'-DDD treatment was associated with a decrease in basal and post-ACTH PACs in dogs with PDH.
对正常犬、垂体依赖性肾上腺皮质功能亢进症（PDH）犬、米托坦（邻，对'-滴滴滴）控制的垂体依赖性肾上腺皮质功能亢进症犬、医源性肾上腺皮质功能亢进症犬和肾上腺皮质功能减退症犬的储存血浆进行了一项回顾性研究，以确定这些疾病中醛固酮生成是否存在改变。在静脉注射促肾上腺皮质激素（ACTH）（0.5 IU/kg）前及注射后1小时，通过放射免疫分析法测定血浆醛固酮浓度（PAC）。给正常犬注射ACTH后，PAC显著升高。PDH犬的基础PAC较低，但注射ACTH后其PAC升高至与正常犬相似的水平。在接受邻，对'-滴滴滴治疗的PDH犬中，对ACTH的反应明显低于正常犬或未经治疗的PDH犬。医源性肾上腺皮质功能亢进症犬的基础和ACTH后PAC均低于正常犬。肾上腺皮质功能减退症犬的基础PAC正常，但注射ACTH后PAC无显著升高。这些发现表明，在多种肾上腺疾病中PAC有显著改变，并且ACTH刺激试验在评估肾上腺疾病中的醛固酮分泌时可能有用。此外，在治疗剂量下，邻，对'-滴滴滴治疗与PDH犬的基础和ACTH后PAC降低有关。
