Goy-Thollot I, Péchereau D, Kéroack S, Dezempte J C, Bonnet J M
Département des Animaux de Compagnie, Ecole Nationale Vétérinaire de Lyon, 1 avenue Bourgelat, 69 280 Marcy l'Etoile, France.
J Small Anim Pract. 2002 Nov;43(11):489-92. doi: 10.1111/j.1748-5827.2002.tb00019.x.
The aim of this study was to evaluate the role of aldosterone as an initiating and/or perpetuating factor in hypertension associated with pituitary-dependent hyperadrenocorticism (PDH) in dogs. Thirteen dogs with PDH and 11 healthy control dogs were used. In all dogs, arterial blood pressure and plasma sodium, potassium, basal aldosterone, post-ACTH aldosterone, basal cortisol and post-ACTH cortisol concentrations were measured. The tests were repeated 10 days and three months after the beginning of o,p'-DDD treatment in PDH dogs. In untreated PDH dogs, plasma aldosterone was significantly decreased, whereas cortisol, sodium and arterial blood pressure were significantly increased compared to healthy dogs. Hypertension remained in most treated PDH dogs despite normalisation of cortisol and persistently low aldosterone levels. These results did not demonstrate that aldosterone is involved in the development and perpetuation of hypertension in PDH. However, glucocorticoids seemed to play a major role as an initiating and perpetuating factor in PDH in dogs.
本研究的目的是评估醛固酮在犬垂体依赖性肾上腺皮质功能亢进（PDH）相关高血压中作为起始和/或持续因素的作用。使用了13只患有PDH的犬和11只健康对照犬。对所有犬测量动脉血压、血浆钠、钾、基础醛固酮、促肾上腺皮质激素刺激后醛固酮、基础皮质醇和促肾上腺皮质激素刺激后皮质醇浓度。在PDH犬开始o,p'-DDD治疗10天和3个月后重复这些测试。在未经治疗的PDH犬中，与健康犬相比，血浆醛固酮显著降低，而皮质醇、钠和动脉血压显著升高。尽管皮质醇恢复正常且醛固酮水平持续较低，但大多数接受治疗的PDH犬仍存在高血压。这些结果并未证明醛固酮参与PDH高血压的发生和持续。然而，糖皮质激素似乎在犬PDH中作为起始和持续因素发挥主要作用。
