慢性持续和间歇性低氧后复氧对红细胞生成的调节。
Regulation of erythropoiesis after normoxic return from chronic sustained and intermittent hypoxia.
机构信息
University of Utah , Salt Lake City, Utah.
出版信息
J Appl Physiol (1985). 2017 Dec 1;123(6):1671-1675. doi: 10.1152/japplphysiol.00119.2017. Epub 2017 May 18.
Abstract
Hypoxia increases erythropoiesis mediated by hypoxia-inducible transcription factors (HIF), which regulate erythropoietin transcription. Neocytolysis is a physiological mechanism that corrects polycythemia from chronic sustained hypoxemia by transient, preferential destruction of young RBCs after normoxia is restored. We showed that neocytolysis is caused by excessive mitochondrial-derived reactive oxygen species in reticulocytes mediated by downregulation of HIF-controlled BNIP3L regulated mitophagy and a decrease in RBC antioxidant catalase (CAT) in hypoxia-produced erythrocytes. Decreased CAT results from hypoxia-induced miR-21 that downregulates CAT. This correlates with a transient acute decrease of HIF-1 at normoxic return that is associated with normalization of red cell mass.
摘要
低氧通过缺氧诱导转录因子 (HIF) 增加红细胞生成，HIF 调节促红细胞生成素的转录。网织红细胞新生溶解是一种生理性机制，通过在恢复正常氧合后短暂优先破坏年轻的 RBC，来纠正慢性持续低氧引起的红细胞增多症。我们表明，网织红细胞中的线粒体来源的活性氧过多是由 HIF 控制的 BNIP3L 调节的线粒体自噬下调和低氧产生的 RBC 中抗氧化酶 CAT 减少引起的。CAT 的减少是由于缺氧诱导的 miR-21 下调 CAT 所致。这与正常氧合恢复时 HIF-1 的短暂急性下降相关，这与红细胞量的正常化相关。
相似文献
1
Regulation of erythropoiesis after normoxic return from chronic sustained and intermittent hypoxia.慢性持续和间歇性低氧后复氧对红细胞生成的调节。
J Appl Physiol (1985). 2017 Dec 1;123(6):1671-1675. doi: 10.1152/japplphysiol.00119.2017. Epub 2017 May 18.
2
HIF-mediated increased ROS from reduced mitophagy and decreased catalase causes neocytolysis.低氧诱导因子（HIF）介导的自噬减少和过氧化氢酶降低导致活性氧（ROS）增加，从而引起新生红细胞溶解。
J Mol Med (Berl). 2015 Aug;93(8):857-66. doi: 10.1007/s00109-015-1294-y. Epub 2015 May 28.
3
Evaluation of Erythrocyte Changes After Normoxic Return from Hypoxia.缺氧后常氧恢复时红细胞变化的评估
Methods Mol Biol. 2018;1742:185-194. doi: 10.1007/978-1-4939-7665-2_16.
4
Neocytolysis: How to Get Rid of the Extra Erythrocytes Formed by Stress Erythropoiesis Upon Descent From High Altitude.新生红细胞溶解：如何清除从高海拔下降时应激性红细胞生成所形成的多余红细胞。
Front Physiol. 2018 Apr 5;9:345. doi: 10.3389/fphys.2018.00345. eCollection 2018.
5
Increased blood reactive oxygen species and hepcidin in obstructive sleep apnea precludes expected erythrocytosis.阻塞性睡眠呼吸暂停症患者血液中活性氧和铁调素增加，阻止了预期的红细胞增多。
Am J Hematol. 2023 Aug;98(8):1265-1276. doi: 10.1002/ajh.26992. Epub 2023 Jun 23.
6
Delayed hemoglobin switching and perinatal neocytolysis in mice with gain-of-function erythropoietin receptor.具有促红细胞生成素受体功能获得性突变的小鼠出现血红蛋白转换延迟和围产期新细胞溶解。
J Mol Med (Berl). 2016 May;94(5):597-608. doi: 10.1007/s00109-015-1375-y. Epub 2015 Dec 26.
7
BNIP3 induction by hypoxia stimulates FASN-dependent free fatty acid production enhancing therapeutic potential of umbilical cord blood-derived human mesenchymal stem cells.缺氧诱导BNIP3可刺激脂肪酸合酶依赖性游离脂肪酸生成，增强脐带血来源的人间充质干细胞的治疗潜力。
Redox Biol. 2017 Oct;13:426-443. doi: 10.1016/j.redox.2017.07.004. Epub 2017 Jul 4.
8
Mieap-induced accumulation of lysosomes within mitochondria (MALM) regulates gastric cancer cell invasion under hypoxia by suppressing reactive oxygen species accumulation.Mieap 诱导的溶酶体在线粒体中的积累（MALM）通过抑制活性氧积累来调节低氧下胃癌细胞的侵袭。
Sci Rep. 2019 Feb 26;9(1):2822. doi: 10.1038/s41598-019-39563-x.
9
Heterozygous HIF-1alpha deficiency impairs carotid body-mediated systemic responses and reactive oxygen species generation in mice exposed to intermittent hypoxia.杂合型缺氧诱导因子-1α缺乏会损害间歇性低氧暴露小鼠中颈动脉体介导的全身反应和活性氧生成。
J Physiol. 2006 Dec 1;577(Pt 2):705-16. doi: 10.1113/jphysiol.2006.114033. Epub 2006 Sep 14.
10
[Effects of intermittent hypoxic exposure on the parameter of erythrocyte and serum hypoxia inducible factor-1 alpha and erythropoietin levels].间歇性低氧暴露对红细胞参数及血清缺氧诱导因子-1α和促红细胞生成素水平的影响
Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2009 Oct;25(10):932-4.
引用本文的文献
1
Response to chronic sustained hypoxia: increased cytosolic gelsolin and decreased plasma gelsolin levels.应对慢性持续缺氧：细胞溶质凝胶蛋白水平升高和血浆凝胶蛋白水平降低。
J Mol Histol. 2024 Oct;55(5):1009-1019. doi: 10.1007/s10735-024-10248-8. Epub 2024 Aug 22.
2
A new role for erythropoietin in the homeostasis of red blood cells.促红细胞生成素在红细胞内稳态中的新作用。
Commun Biol. 2024 Jan 8;7(1):58. doi: 10.1038/s42003-023-05758-2.
3
MiR-21 Is Induced by Hypoxia and Down-Regulates in Prostate Cancer.微小RNA-21由缺氧诱导并在前列腺癌中下调。
Cancers (Basel). 2023 Feb 17;15(4):1291. doi: 10.3390/cancers15041291.
4
[Analysis of related factors in secondary erythrocytosis of obstructive sleep apnea hypopnea syndrome in Gansu province].[甘肃省阻塞性睡眠呼吸暂停低通气综合征继发性红细胞增多症相关因素分析]
Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2022 May;36(5):338-342. doi: 10.13201/j.issn.2096-7993.2022.05.003.
5
Is obstructive sleep apnea associated with erythrocytosis? A systematic review and meta-analysis.阻塞性睡眠呼吸暂停与红细胞增多症有关吗？一项系统评价和荟萃分析。
Laryngoscope Investig Otolaryngol. 2022 Feb 2;7(2):627-635. doi: 10.1002/lio2.751. eCollection 2022 Apr.
6
Upregulated heme biosynthesis increases obstructive sleep apnea severity: a pathway-based Mendelian randomization study.血红素生物合成上调增加阻塞性睡眠呼吸暂停严重程度：基于途径的孟德尔随机化研究。
Sci Rep. 2022 Jan 27;12(1):1472. doi: 10.1038/s41598-022-05415-4.
7
Obstructive Sleep Apnea is Associated with an Increased Prevalence of Polycythemia in Patients with Chronic Obstructive Pulmonary Disease.阻塞性睡眠呼吸暂停与慢性阻塞性肺疾病患者红细胞增多症的患病率增加有关。
Int J Chron Obstruct Pulmon Dis. 2022 Jan 15;17:195-204. doi: 10.2147/COPD.S338824. eCollection 2022.
8
Hypoxia induces de novo formation of cerebral collaterals and lessens the severity of ischemic stroke.缺氧可诱导脑侧支新生，减轻缺血性脑卒中的严重程度。
J Cereb Blood Flow Metab. 2020 Sep;40(9):1806-1822. doi: 10.1177/0271678X20924107. Epub 2020 May 19.
9
Nocturnal Mean Oxygen Saturation Is Associated with Secondary Polycythemia in Young Adults with Obstructive Sleep Apnea, Especially in Men.夜间平均血氧饱和度与阻塞性睡眠呼吸暂停年轻成人的继发性红细胞增多症相关，尤其是男性。
Nat Sci Sleep. 2019 Dec 5;11:377-386. doi: 10.2147/NSS.S226143. eCollection 2019.
10
Guinea Pig as a Model to Study the Carotid Body Mediated Chronic Intermittent Hypoxia Effects.豚鼠作为研究颈动脉体介导的慢性间歇性缺氧效应的模型。
Front Physiol. 2018 Jun 5;9:694. doi: 10.3389/fphys.2018.00694. eCollection 2018.
本文引用的文献
1
Inflammation-Induced Expression and Secretion of MicroRNA 122 Leads to Reduced Blood Levels of Kidney-Derived Erythropoietin and Anemia.炎症诱导 microRNA-122 的表达和分泌，导致肾脏来源的促红细胞生成素血水平降低和贫血。
Gastroenterology. 2016 Nov;151(5):999-1010.e3. doi: 10.1053/j.gastro.2016.07.031. Epub 2016 Jul 29.
2
Measuring End-Tidal Carbon Monoxide of Jaundiced Neonates in the Birth Hospital to Identify Those with Hemolysis.在产院测量黄疸新生儿的呼末一氧化碳以识别溶血患儿。
Neonatology. 2016;109(1):1-5. doi: 10.1159/000438482. Epub 2015 Sep 23.
3
HIF-mediated increased ROS from reduced mitophagy and decreased catalase causes neocytolysis.低氧诱导因子（HIF）介导的自噬减少和过氧化氢酶降低导致活性氧（ROS）增加，从而引起新生红细胞溶解。
J Mol Med (Berl). 2015 Aug;93(8):857-66. doi: 10.1007/s00109-015-1294-y. Epub 2015 May 28.
4
Progress on hypoxia-inducible factor-3: Its structure, gene regulation and biological function (Review).缺氧诱导因子-3的研究进展：其结构、基因调控及生物学功能（综述）
Mol Med Rep. 2015 Aug;12(2):2411-6. doi: 10.3892/mmr.2015.3689. Epub 2015 Apr 27.
5
End-tidal carbon monoxide as an indicator of the hemolytic rate.呼末一氧化碳作为溶血率的指标。
Blood Cells Mol Dis. 2015 Mar;54(3):292-6. doi: 10.1016/j.bcmd.2014.11.018. Epub 2014 Nov 26.
6
Is obstructive sleep apnoea syndrome really one of the causes of secondary polycythaemia?阻塞性睡眠呼吸暂停综合征真的是继发性红细胞增多症的病因之一吗？
Hematology. 2015 Mar;20(2):108-11. doi: 10.1179/1607845414Y.0000000170. Epub 2014 May 6.
7
Reactive oxygen species in inflammation and tissue injury.炎症和组织损伤中的活性氧。
Antioxid Redox Signal. 2014 Mar 1;20(7):1126-67. doi: 10.1089/ars.2012.5149. Epub 2013 Oct 22.
8
Is malarial anaemia homologous to neocytolysis after altitude acclimatisation?疟疾性贫血与高原适应后新生细胞溶解是否同源？
Int J Parasitol. 2014 Jan;44(1):19-22. doi: 10.1016/j.ijpara.2013.06.011. Epub 2013 Aug 17.
9
Iron regulation by hepcidin.亚铁离子调控素对铁的调节作用。
J Clin Invest. 2013 Jun;123(6):2337-43. doi: 10.1172/JCI67225. Epub 2013 Jun 3.
10
Opposite effects of HIF-1α and HIF-2α on the regulation of IL-8 expression in endothelial cells.HIF-1α 和 HIF-2α 对内皮细胞中 IL-8 表达的调节具有相反的作用。
Free Radic Biol Med. 2011 Nov 15;51(10):1882-92. doi: 10.1016/j.freeradbiomed.2011.08.023. Epub 2011 Aug 30.
Zotero 插件