Parker Dane
Department of Pediatrics, Columbia University, New York, NY, USA.
Front Immunol. 2017 May 4;8:512. doi: 10.3389/fimmu.2017.00512. eCollection 2017.
is a successful human pathogen that has adapted itself in response to selection pressure by the human immune system. A commensal of the human skin and nose, it is a leading cause of several conditions: skin and soft tissue infection, pneumonia, septicemia, peritonitis, bacteremia, and endocarditis. Mice have been used extensively in all these conditions to identify virulence factors and host components important for pathogenesis. Although significant effort has gone toward development of an anti-staphylococcal vaccine, antibodies have proven ineffective in preventing infection in humans after successful studies in mice. These results have raised questions as to the utility of mice to predict patient outcome and suggest that humanized mice might prove useful in modeling infection. The development of humanized mouse models of infection will allow us to assess the contribution of several human-specific virulence factors, in addition to exploring components of the human immune system in protection against infection. Their use is discussed in light of several recently reported studies.
是一种成功的人类病原体，它已根据人类免疫系统的选择压力进行了自我适应。它是人类皮肤和鼻腔的共生菌，是多种病症的主要病因：皮肤和软组织感染、肺炎、败血症、腹膜炎、菌血症和心内膜炎。在所有这些病症中，小鼠都被广泛用于鉴定对发病机制重要的毒力因子和宿主成分。尽管在开发抗葡萄球菌疫苗方面付出了巨大努力，但在小鼠身上进行成功研究后，抗体在预防人类感染方面已被证明无效。这些结果引发了关于小鼠预测患者预后效用的疑问，并表明人源化小鼠可能在感染建模中有用。感染的人源化小鼠模型的开发将使我们能够评估几种人类特异性毒力因子的作用，此外还能探索人类免疫系统在抗感染中的组成部分。根据最近报道的几项研究对它们的用途进行了讨论。
