亮肌抑制素是一种新型昆虫神经肽，可抑制黄粉虫神经肌肉接头处的诱发递质释放。

Leucomyosuppressin, a novel insect neuropeptide, inhibits evoked transmitter release at the mealworm neuromuscular junction.

作者信息

Yamamoto D, Ishikawa S, Holman G M, Nachman R J

机构信息

Laboratory of Neurophysiology, Mitsubishi-Kasei Institute of Life Sciences, Tokyo, Japan.

出版信息

Neurosci Lett. 1988 Dec 19;95(1-3):137-42. doi: 10.1016/0304-3940(88)90646-5.

DOI:10.1016/0304-3940(88)90646-5

PMID:2852317

Abstract

The action of leucomyosuppressin (LMS: pGlu-Asp-Val-Asp-His-Val-Phe-Leu-Arg-Phe-NH2) on the glutamate-mediated neuromuscular transmission in the mealworm, Tenebrio molitor, was studied by the microelectrode current-clamp and voltage-clamp techniques. Submicromolar concentrations of LMS reversibly attenuate evoked release of transmitter from the motor nerve terminals, as evidenced by a decrease in the quantum content estimated by the number of failures of extracellular EPSPs. LMS has no effect on the glutamate-induced depolarization. Possible intracellular mediators for the LMS action are discussed.

摘要

通过微电极电流钳和电压钳技术，研究了白细胞肌抑制素（LMS：焦谷氨酸-天冬氨酸-缬氨酸-天冬氨酸-组氨酸-缬氨酸-苯丙氨酸-亮氨酸-精氨酸-苯丙氨酸-NH2）对黄粉虫（Tenebrio molitor）中谷氨酸介导的神经肌肉传递的作用。亚微摩尔浓度的LMS可逆地减弱运动神经末梢递质的诱发释放，细胞外兴奋性突触后电位（EPSP）失败次数估计的量子含量降低证明了这一点。LMS对谷氨酸诱导的去极化没有影响。讨论了LMS作用可能的细胞内介质。