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Cholecystokinin modulates neurotransmission through the dentate gyrus.

作者信息

Sinton C M

机构信息

Research Department, Ciba-Geigy Corp., Summit, NJ 07901.

出版信息

Neurosci Lett. 1988 Dec 19;95(1-3):341-6. doi: 10.1016/0304-3940(88)90682-9.

DOI:10.1016/0304-3940(88)90682-9
PMID:2852324
Abstract

The sulfated and unsulfated cholecystokinin (CCK) octapeptide sequences and the pancreatic CCK antagonists, CR 1409 and benzotript, were administered iontophoretically while dentate gyrus granule cell activity was recorded in the anesthetized rat. During application of the compounds, the peri-stimulus time histogram (PSTH) was constructed of granule cell activity coupled to stimulation of the sciatic nerve. CCK and CR 1409, but not benzotript, were found to change significantly the PSTH by enhancing and prolonging the response to sensory stimulation. These results are interpreted as indicating that CCK can modulate impulse flow through the dentate gyrus.

摘要

相似文献

1
Cholecystokinin modulates neurotransmission through the dentate gyrus.
Neurosci Lett. 1988 Dec 19;95(1-3):341-6. doi: 10.1016/0304-3940(88)90682-9.
2
Cholecystokinin and cholecystokinin antagonists enhance postsynaptic excitability in the dentate gyrus.
Peptides. 1988 Sep-Oct;9(5):1049-53. doi: 10.1016/0196-9781(88)90087-3.
3
Cholecystokinin and an evoked response in the dentate gyrus.胆囊收缩素与齿状回中的诱发反应。
Neuropeptides. 1988 Jul;12(1):29-34. doi: 10.1016/s0143-4179(98)90006-3.
4
The effects of cholecystokinin and cholecystokinin antagonists on synaptic function in the CA1 region of the rat hippocampal slice.胆囊收缩素及胆囊收缩素拮抗剂对大鼠海马脑片CA1区突触功能的影响。
Brain Res. 1987 Jul 7;415(1):197-203. doi: 10.1016/0006-8993(87)90288-5.
5
Antagonists of central and peripheral behavioral actions of cholecystokinin octapeptide.胆囊收缩素八肽中枢和外周行为作用的拮抗剂。
J Pharmacol Exp Ther. 1986 Feb;236(2):320-30.
6
Inhibition of synaptic transmission in the hippocampus by cholecystokinin (CCK) and its antagonism by a CCK analog (CCK27-33).
Brain Res. 1987 Mar 17;406(1-2):130-5. doi: 10.1016/0006-8993(87)90777-3.
7
The effect of cholecystokinin-receptor antagonists on cholecystokinin-stimulated bile flow in dogs.
Surgery. 1991 Mar;109(3 Pt 1):294-300.
8
Systemically administered cholecystokinin affects an evoked potential in the hippocampal dentate gyrus.
Neuropeptides. 1987 Aug-Sep;10(2):165-73. doi: 10.1016/0143-4179(87)90018-7.
9
Cholecystokinin-dopamine receptor interactions as studied with cholecystokinin receptor antagonists.用胆囊收缩素受体拮抗剂研究胆囊收缩素-多巴胺受体相互作用
Prog Clin Biol Res. 1985;192:105-13.
10
Unsulfated CCK-8 not blocked by proglumide or CR 1409 in the mouse abdominal irritant-induced stretching assay: possible central site of action.在小鼠腹部刺激诱导的伸展试验中，未硫酸化的CCK-8不受丙谷胺或CR 1409的阻断：可能的中枢作用位点。
Peptides. 1989 Jan-Feb;10(1):31-4. doi: 10.1016/0196-9781(89)90071-5.

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Cholecystokinin facilitates glutamate release by increasing the number of readily releasable vesicles and releasing probability.胆囊收缩素通过增加易释放囊泡的数量和释放概率来促进谷氨酸的释放。
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