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临床证据与生物学证据的相关性——异位妊娠成功治疗的关键要素。

Correlation of clinical and biological evidence - a dominant therapeutic element of succeeding in ectopic pregnancy.

作者信息

NeamŢu Simona Daniela, DiŢescu Damian, ForŢofoiu Maria, Stanca Liliana, Tigae Cristian, Niculescu Mihaela, NeamŢu Cristian Ovidiu, Manolea Maria Magdalena, Siminel Mirela Anişoara, Şurtea Leontina Eugenia, NeamŢu Adela Valeria, Novac Marius Bogdan, Vasile Liviu, Gluhovschi Adrian

机构信息

Department of Neonatology, University of Medicine and Pharmacy of Craiova, Romania;

出版信息

Rom J Morphol Embryol. 2017;58(1):167-174.

PMID:28523313
Abstract

Tubal pathology, smoking, pelvic inflammatory disease, miscarriage, medical or surgical abortion, usage of intrauterine devices (IUDs) for women with salpingitis latent injuries, older than 40 years, are risk factors for ectopic pregnancy. The objective of this study concerns the correlation of the clinical and biological evidence for the early diagnosis of the ectopic pregnancy and, as soon as possible, for the estimation for eventual risk of complications that may appear. The transvaginal ultrasound test, minimal increases in serum beta-human chorionic gonadotropin (β-hCG) dynamics and blood counts are investigations of choice in achieving our objective. Overcoming β-hCG critical level (>1198 IU÷mL), the decrease of platelets and changes in platelet constants announce the imminent risk of ectopic pregnancy rupture and the need to take a quick decision on the course of treatment.

摘要

输卵管病变、吸烟、盆腔炎、流产、药物流产或手术流产、对有潜在输卵管炎损伤的女性使用宫内节育器(IUD)、年龄超过40岁等,都是异位妊娠的危险因素。本研究的目的是探讨临床和生物学证据与异位妊娠早期诊断的相关性,并尽快评估可能出现的并发症的最终风险。经阴道超声检查、血清β-人绒毛膜促性腺激素(β-hCG)动态轻微升高以及血常规检查是实现我们目标的首选检查。当β-hCG超过临界水平(>1198 IU÷mL)时,血小板减少以及血小板常数的变化预示着异位妊娠即将破裂的风险,需要迅速决定治疗方案。

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Correlation of clinical and biological evidence - a dominant therapeutic element of succeeding in ectopic pregnancy.临床证据与生物学证据的相关性——异位妊娠成功治疗的关键要素。
Rom J Morphol Embryol. 2017;58(1):167-174.
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Human chorionic gonadotropin level as a predictor of trophoblastic infiltration into the tubal wall in ectopic pregnancy: a blinded study.人绒毛膜促性腺激素水平作为异位妊娠中滋养层细胞浸润输卵管壁的预测指标:一项盲法研究。
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Efficacy and safety of a clinical protocol for expectant management of selected women diagnosed with a tubal ectopic pregnancy.期待治疗诊断为输卵管异位妊娠的特定女性患者的临床方案的疗效和安全性。
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Tubal conservation with ectopic gestations. A reappraisal.异位妊娠时的输卵管保留。重新评估。
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The multiple ultrasound patterns of ectopic pregnancy.异位妊娠的多种超声表现
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[Expectative management: a valid option for ectopic pregnancy].期待治疗:异位妊娠的一种有效选择
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Methotrexate or expectant management in women with an ectopic pregnancy or pregnancy of unknown location and low serum hCG concentrations? A randomized comparison.甲氨蝶呤或期待疗法治疗血清人绒毛膜促性腺激素浓度低的异位妊娠或不明位置妊娠妇女?一项随机比较。
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Predictive factors of trophoblastic invasion into the ampullary region of the tubal wall in ectopic pregnancy.异位妊娠时滋养细胞侵入输卵管壁壶腹部区域的预测因素。
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Tubal ectopic pregnancy occurrence is associated with high expressions of prokineticin receptors and aberrant secretion of inflammatory cytokines.输卵管异位妊娠的发生与促动力蛋白受体的高表达及炎性细胞因子的异常分泌有关。
Am J Transl Res. 2020 Sep 15;12(9):5741-5751. eCollection 2020.