Watson Peter N C, Evans Ramon J, Watt Verna R, Birkett N
Smythe Pain Clinic, Toronto General Hospital, University of Toronto, Toronto, Ont. M5G 2C4 Canada.
Pain. 1988 Dec;35(3):289-297. doi: 10.1016/0304-3959(88)90139-X.
Two hundred and eight patients with post-herpetic neuralgia (PHN) were assessed in a prospective, longitudinal study designed to evaluate demography, clinical features, treatment results and long-term status. PHN affected both sexes equally increasing in frequency and severity with age. There was a predilection for involvement of the ophthalmic division of the trigeminal nerve and for mid-thoracic dermatomes. The pain descriptors chosen reflected both steady and brief paroxysmal components in most patients. Scarring, sensory loss and the exaggerated sensations of hyperesthesia, dysesthesia and allodynia were common findings. Hyperalgesia and hyperpathia were less common. From these open-label, uncontrolled data, antidepressants (amitriptyline and nortriptyline) appeared useful in about 60% of patients. Topical capsaicin seemed to be a promising new approach. A variety of other pharmacological agents and treatment approaches were less successful. Many patients with PHN even of long standing continued to improve with time.
在一项旨在评估人口统计学、临床特征、治疗结果和长期状况的前瞻性纵向研究中，对208例带状疱疹后神经痛（PHN）患者进行了评估。PHN对男女的影响相同，其发病率和严重程度均随年龄增长而增加。三叉神经眼支和胸中段皮节受累较为常见。大多数患者选择的疼痛描述词反映了稳定和短暂的阵发性成分。瘢痕形成、感觉丧失以及感觉过敏、感觉异常和痛觉过敏等夸张感觉是常见表现。痛觉过敏和感觉过度则较少见。从这些开放标签、无对照的数据来看，抗抑郁药（阿米替林和去甲替林）似乎对约60%的患者有效。局部用辣椒素似乎是一种有前景的新方法。其他多种药物和治疗方法效果较差。许多患有PHN的患者，即使病程较长，也会随着时间的推移而持续改善。
