Fattori Victor, Hohmann Miriam S N, Rossaneis Ana C, Pinho-Ribeiro Felipe A, Verri Waldiceu A
Departamento de Ciências Patológicas, Centro de Ciências Biológicas, Universidade Estadual de Londrina, Rodovia Celso Garcia Cid KM480 PR445, Caixa Postal 10.011, 86057-970 Londrina, Paraná, Brazil.
Molecules. 2016 Jun 28;21(7):844. doi: 10.3390/molecules21070844.
In this review, we discuss the importance of capsaicin to the current understanding of neuronal modulation of pain and explore the mechanisms of capsaicin-induced pain. We will focus on the analgesic effects of capsaicin and its clinical applicability in treating pain. Furthermore, we will draw attention to the rationale for other clinical therapeutic uses and implications of capsaicin in diseases such as obesity, diabetes, cardiovascular conditions, cancer, airway diseases, itch, gastric, and urological disorders.
在本综述中，我们讨论了辣椒素对于当前理解神经元对疼痛的调节作用的重要性，并探讨了辣椒素诱发疼痛的机制。我们将重点关注辣椒素的镇痛作用及其在疼痛治疗中的临床适用性。此外，我们将关注辣椒素在肥胖症、糖尿病、心血管疾病、癌症、气道疾病、瘙痒、胃肠道和泌尿系统疾病等其他临床治疗用途的基本原理及意义。
