Department of Emergency, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, No. 17 Renmin Nan Road, Chengdu, 610041, China.
Department of Chemistry, Yale University, New Haven, CT, 06520-8107, USA.
Angew Chem Int Ed Engl. 2017 Jun 12;56(25):7213-7217. doi: 10.1002/anie.201703029. Epub 2017 May 19.
A copper/borinic acid dual catalytic reaction enabled the enantioselective propargylation of aliphatic polyols. Readily available reagents and catalysts were used in this transformation, which displayed good to excellent chemo- and stereoselectivity for a broad array of substrates. The method was also applicable to the desymmetrization of meso 1,2-diols to furnish products with three stereogenic centers and a terminal alkyne group in one operation.
铜/硼酸双催化反应实现了脂肪族多元醇的对映选择性炔丙基化反应。该转化使用了易得的试剂和催化剂，对广泛的底物表现出良好到优秀的化学和立体选择性。该方法也适用于外消旋 1,2-二醇的去对称化，以在一步反应中得到具有三个手性中心和末端炔基的产物。
