Department of Dermatology, CHRU, Tours, France, University François-Rabelais, Tours, France.
Department of Dermatology, CHRU, Tours, France.
Eur J Dermatol. 2017 Jun 1;27(3):260-265. doi: 10.1684/ejd.2017.3015.
Neurofibromas (NFs) are benign tumours arising from a nerve sheath, which are present in nearly all patients with neurofibromatosis type 1 (NF1). High-frequency ultrasound (HFU) systems, using frequencies over 20 MHz, were developed to improve visualization of skin tumours by means of increased resolution. To describe NFs by using HFU in patients with NF1. Anonymized HFU (25-MHz) images of NFs were randomized. Initially, two dermatologist investigators, with experience in HFU imaging of the skin, together described the ultrasound images and established eight criteria for NFs. The same task was then repeated by two other dermatologists, also with experience in HFU imaging of the skin, independently, to establish inter-observer agreement. A total of 108 NFs in 29 patients were included. Superficial and subcutaneous NFs were hypoechoic with a round to spindle shape. Plexiform NFs were ill-defined, consisting of multiple hypoechoic linear zones. Good to excellent inter-observer agreement was found for six of the eight criteria (k>0.6). This is the first series describing HFU skin imaging of NFs in patients with NF1. Lateral extension that may correspond to involvement of an adjacent nerve seems to be specific to NFs.
神经纤维瘤（NFs）是起源于神经鞘的良性肿瘤，几乎存在于所有 1 型神经纤维瘤病（NF1）患者中。高频超声（HFU）系统使用超过 20MHz 的频率，旨在通过提高分辨率来改善皮肤肿瘤的可视化。描述 NF1 患者的 HFU 下 NFs。对匿名 HFU（25MHz）NFs 图像进行随机化。最初，两位具有皮肤 HFU 成像经验的皮肤科医生共同描述了超声图像，并确定了 8 个 NF 标准。然后，另外两位具有皮肤 HFU 成像经验的皮肤科医生独立重复相同的任务，以建立观察者间的一致性。共纳入 29 例患者的 108 个 NFs。浅表和皮下 NFs 呈低回声，呈圆形至梭形。丛状 NFs 边界不清，由多个低回声线性区域组成。八项标准中的六项具有较好到极好的观察者间一致性（k>0.6）。这是第一系列描述 NF1 患者 HFU 皮肤成像的 NFs。似乎与相邻神经受累相对应的侧向延伸是 NF 的特异性表现。
