母亲职业性体力活动与口面部裂隙风险
Maternal occupational physical activity and risk for orofacial clefts.
作者信息
Agopian A J, Kim Jihye, Langlois Peter H, Lee Laura, Whitehead Lawrence W, Symanski Elaine, Herdt Michele L, Delclos George L
机构信息
Department of Epidemiology, Human Genetics and Environmental Sciences, UTHealth School of Public Health, Houston, Texas.
Birth Defects Epidemiology and Surveillance Branch, Texas Department of State Health Services, Austin, Texas.
出版信息
Am J Ind Med. 2017 Jul;60(7):627-634. doi: 10.1002/ajim.22731. Epub 2017 May 19.
OBJECTIVES
To perform a case-control study of maternal occupational physical activity and risk for orofacial clefts in Texas during 1999-2009.
METHODS
We used logistic regression to assess 14 measures of physical activity estimated from a job exposure matrix, using the maternal occupation reported on the birth certificate, among 887 children with cleft lip with or without cleft palate (CLP), 436 children with cleft palate only (CP), and 1932 controls.
RESULTS
After adjusting for several potential confounders, seven measures of physical activity (as a categorical and/or continuous variable) were significantly associated with CLP, CP, or both. Positive associations were seen for keeping balance, kneeling, standing, and walking/running (odds ratio 95% confidence interval range 1.0-1.9 for fourth versus first quartile). A significant positive trend was also seen for bending/twisting. Negative associations were seen for repetitive motion and sitting.
CONCLUSIONS
Maternal occupational physical activity may be related to the etiology of orofacial clefts.
目的
开展一项病例对照研究，探究1999 - 2009年德克萨斯州孕妇职业体力活动与口面部裂隙风险之间的关系。
方法
我们采用逻辑回归分析，根据出生证明上报告的母亲职业，利用工作暴露矩阵估算的14项体力活动指标，对887例唇裂伴或不伴腭裂（CLP）患儿、436例单纯腭裂（CP）患儿以及1932例对照进行评估。
结果
在对多个潜在混杂因素进行调整后，7项体力活动指标（作为分类变量和/或连续变量）与CLP、CP或两者均显著相关。保持平衡、跪、站以及行走/跑步呈现正相关（四分位数第四组与第一组相比，优势比95%置信区间范围为1.0 - 1.9）。弯腰/扭转也呈现显著的正相关趋势。重复性动作和坐呈现负相关。
结论
孕妇职业体力活动可能与口面部裂隙的病因有关。
Zotero 插件