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Characteristics of Factors Influencing the Occurrence of Cleft Lip and/or Palate: A Case Analysis and Literature Review.

作者信息

Kulesa-Mrowiecka Małgorzata, Lipowicz Anna, Marszałek-Kruk Bożena Anna, Kania Damian, Wolański Wojciech, Myśliwiec Andrzej, Dowgierd Krzysztof

机构信息

Department of Rehabilitation in Internal Diseases, Institute of Physiotherapy, Faculty of Health Sciences, Jagiellonian University Medical College, 31-126 Krakow, Poland.

Department of Anthropology, Institute of Environmental Biology, Wroclaw University of Environmental and Life Sciences, 50-375 Wroclaw, Poland.

出版信息

Children (Basel). 2024 Mar 28;11(4):399. doi: 10.3390/children11040399.


DOI:10.3390/children11040399
PMID:38671616
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11049449/
Abstract

INTRODUCTION: Cleft lip with or without cleft palate (CL/P) stands as the most common congenital facial anomaly, stemming from multifactorial causes. OBJECTIVE: Our study aimed to ascertain the prevalence and characteristics of cleft palates, identify associated risk factors to inform prevention and prenatal detection for early intervention, and assess postoperative rehabilitation protocols for cleft palates. DESIGN: This study employs a retrospective descriptive and clinical approach. PATIENTS: The study includes 103 children with cleft palates treated at the Department of Head and Neck Surgery Clinic for Children and Young Adults, Department of Clinical Pediatrics, University of Warmia and Mazury. METHODS: We conducted a thorough evaluation of records, considering variables such as sex, cleft type, maternal occupation, parental education, and family history of clefts. Data analysis was carried out using R software version GPL-3 and ordinal logistic regression analyses. RESULTS: Notably, children born to mothers who experienced significant stress during pregnancy exhibited a 9.4-fold increase in the odds of having bilateral cleft palates. Conversely, no substantial evidence was found to support the influence of the child's sex, birth order, body mass, maternal exposure to workplace toxins, infections, or drug toxicity on the dependent variable. CONCLUSIONS: Our findings suggest that children with parents who have a history of clefts and those with less educated mothers are more likely to develop bilateral cleft palates. Additionally, children born to mothers experiencing stress during pregnancy face an increased risk of bilateral cleft palates. It is important to note that there is a paucity of literature on rehabilitation following various cleft palate surgical techniques in children.

摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c82e/11049449/ac23ef7cb003/children-11-00399-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c82e/11049449/15ed6bf79e82/children-11-00399-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c82e/11049449/ac23ef7cb003/children-11-00399-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c82e/11049449/15ed6bf79e82/children-11-00399-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c82e/11049449/ac23ef7cb003/children-11-00399-g002.jpg

相似文献

[1]
Characteristics of Factors Influencing the Occurrence of Cleft Lip and/or Palate: A Case Analysis and Literature Review.

Children (Basel). 2024-3-28

[2]
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[6]
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[7]
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[8]
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[9]
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Prevalence, trend, and associated risk factors for cleft lip with/without cleft palate: a national study on live births from 2016 to 2021.

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引用本文的文献

[1]
Three-dimensional assessment of maxillary arch changes in infants with bilateral cleft lip and palate using vacuum-formed nasoalveolar molding with active screw versus conventional nasoalveolar molding appliances: a randomized clinical trial.

BMC Oral Health. 2025-8-19

[2]
The impact of maternal systemic diseases on the occurrence of cleft lip and palate in newborns: a narrative review.

Front Public Health. 2025-8-1

[3]
[Factors influencing maxillary dental arch development in children after Sommerlad-Furlow palatoplasty].

Hua Xi Kou Qiang Yi Xue Za Zhi. 2025-4-1

[4]
Three-dimensional analysis of palatal morphology and PAS in patients with cleft lip and palate prior to orthodontic treatment.

Head Face Med. 2024-8-1

本文引用的文献

[1]
Modifiable Risk Factors of Non-Syndromic Orofacial Clefts: A Systematic Review.

Children (Basel). 2022-11-28

[2]
Maternal Cigarette Smoking and Cleft Lip and Palate: A Systematic Review and Meta-Analysis.

Cleft Palate Craniofac J. 2022-9

[3]
Prevalence of cleft lip and palate and associated factors in Brazil's Midwest: a single-center study.

Braz Oral Res. 2021-4-26

[4]
Risk of non-syndromic orofacial clefts by maternal rural-urban residence and race/ethnicity: A population-based case-control study in Washington State 1989-2014.

Paediatr Perinat Epidemiol. 2021-5

[5]
Frequency of Additional Congenital Dental Anomalies in Children with Cleft Lip, Alveolar and Palate.

J Clin Med. 2020-11-25

[6]
Prenatal Exposures Are Associated With Worse Neurodevelopmental Outcomes in Infants With Neonatal Opioid Withdrawal Syndrome.

Front Pediatr. 2020-8-27

[7]
Assessment of the correlation between various risk factors and orofacial cleft disorder spectrum: a retrospective case-control study.

Maxillofac Plast Reconstr Surg. 2020-8-8

[8]
Cleft Lip and Palate in Newborns Diagnosed With Neonatal Abstinence Syndrome.

Otolaryngol Head Neck Surg. 2021-1

[9]
Population Attributable Fractions of Modifiable Risk Factors for Nonsyndromic Orofacial Clefts: A Prospective Cohort Study From the Japan Environment and Children's Study.

J Epidemiol. 2021-4-5

[10]
Heterogeneous conceptualization of etiopathogenesis: Oral pyogenic granuloma.

Natl J Maxillofac Surg. 2019

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