Sayag D, Fournel-Fleury C, Ponce F
Clinical Oncology Unit, Université de Lyon, VetAGro Sup Campus Veterinaire, Marcy l'Etoile, France.
Laboratoire de cytologie vétérinaire Fournel-Fleury, Technipath, 41 allée des Cyprès, Limonest, France.
Vet Comp Oncol. 2018 Mar;16(1):12-19. doi: 10.1111/vco.12320. Epub 2017 May 19.
Correlation between morphotypes and prognosis of canine lymphomas presented discordant results in literature, leading to some dilemma for application in clinical practice. The aim of this study was to present a systematic review of literature on the prognostic significance of morphotypes in canine lymphomas. Standardized Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) criteria were applied. Retrospective and prospective studies were included. Level of evidence was determined for each study. Some acceptable evidence suggested a significant prognostic impact of morphotypes in canine lymphomas. However, the evidence is not sufficiently robust to determine with precision the most appropriate classification scheme. Updated Kiel and World Health Organization (WHO) classifications seem to remain the most appropriate classification systems with regards to the number of available studies and their levels of evidence. Limitations included lack of randomized control trial, and relative lack of prospective studies available. Current recommended classification of canine lymphoma is the systematic determination of morphotype in each new case. The Updated Kiel and the WHO classifications adapted to dog both remain the schemes with the most valuable interest. Prospective studies in larger population, and international consensus to define precisely each morphotype, are warranted, with application of standardized staging method and treatment.
犬淋巴瘤形态类型与预后之间的相关性在文献中呈现出不一致的结果，这给临床实践中的应用带来了一些困境。本研究的目的是对关于犬淋巴瘤形态类型预后意义的文献进行系统综述。应用了系统评价和Meta分析的标准化首选报告项目（PRISMA）标准。纳入了回顾性和前瞻性研究。确定了每项研究的证据水平。一些可接受的证据表明形态类型对犬淋巴瘤有显著的预后影响。然而，证据不够充分，无法精确确定最合适的分类方案。就现有研究数量及其证据水平而言，更新后的基尔分类法和世界卫生组织（WHO）分类法似乎仍然是最合适的分类系统。局限性包括缺乏随机对照试验，以及相对缺乏可用的前瞻性研究。目前推荐的犬淋巴瘤分类方法是在每个新病例中系统地确定形态类型。适用于犬的更新后的基尔分类法和WHO分类法仍然是最具价值的方案。有必要在更大的人群中进行前瞻性研究，并达成国际共识以精确界定每种形态类型，同时应用标准化的分期方法和治疗方法。
