血管内皮生长因子A、C和D在HIV相关子痫前期中的作用。
Effect of vascular endothelial growth factors A, C, and D in HIV-associated pre-eclampsia.
作者信息
Shange Gugulethu Promise, Moodley Jagidesa, Naicker Thajasvarie
机构信息
a Optics and Imaging Centre, Women's Health and HIV Research Unit, Nelson R. Mandela School of Medicine, College of Health Sciences, University of KwaZulu-Natal, Durban , South Africa.
出版信息
Hypertens Pregnancy. 2017 May;36(2):196-203. doi: 10.1080/10641955.2017.1297821. Epub 2017 May 19.
OBJECTIVE
To measure and correlate the level of vascular endothelial growth factors A, C, and D in HIV-associated pre-eclampsia.
METHODS
VEGF-A, VEGF-C, and VEGF-D were measured in serum of 76 normotensive and pre-eclamptic pregnant women stratified by HIV status using Bio-Plex.
RESULTS
No significant difference was shown between pre-eclamptic and normotensive and between HIV negative and positive women. A strong significant positive correlation was demonstrated between VEGF-A and VEGF-C, VEGF-A and VEGF-D, and VEGF-C and VEGF D (p < 0.0001).
CONCLUSION
This study demonstrates a significant correlation between VEGF-A, VEGF-C, and VEGF-D and no difference in pre-eclamptic and normotensive pregnant women stratified by HIV status suggesting some neutralization of the immune response in HIV-associated pre-eclampsia.
目的
测量并关联人类免疫缺陷病毒（HIV）相关子痫前期患者血管内皮生长因子A、C和D的水平。
方法
使用生物芯片技术（Bio-Plex）对76名根据HIV感染状况分层的血压正常及子痫前期孕妇的血清进行血管内皮生长因子A（VEGF-A）、血管内皮生长因子C（VEGF-C）和血管内皮生长因子D（VEGF-D）的检测。
结果
子痫前期孕妇与血压正常孕妇之间、HIV阴性与阳性女性之间均未显示出显著差异。VEGF-A与VEGF-C、VEGF-A与VEGF-D、VEGF-C与VEGF-D之间均显示出强显著正相关（p < 0.0001）。
结论
本研究表明VEGF-A、VEGF-C和VEGF-D之间存在显著相关性，且根据HIV感染状况分层的子痫前期孕妇与血压正常孕妇之间无差异，这表明在HIV相关子痫前期中免疫反应存在某种中和作用。
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