Anlar Hatice Gul, Bacanli Merve, İritaş Servet, Bal Ceylan, Kurt Türker, Tutkun Engin, Hinc Yilmaz O, Basaran Nursen
a Department of Pharmaceutical Toxicology , Faculty of Pharmacy, Hacettepe University , Ankara , Turkey.
b Department of Pharmaceutical Toxicology , Faculty of Pharmacy, Çukurova University , Adana , Turkey.
J Toxicol Environ Health A. 2017;80(13-15):688-696. doi: 10.1080/15287394.2017.1286923. Epub 2017 May 19.
Silica is the second most common element after oxygen, and therefore, exposures to crystalline silica dust occur in a large variety of occupations such as metal foundries, constructions, and ceramic, quarry, and pottery industries. Since crystalline silica exposure has been linked with silicosis, lung cancer, and other pulmonary diseases, adverse effect attributed to this element has be a cause for concern worldwide. Silica dust exposure in workers is still considered to be important health problem especially in developing countries. The aim of the study was to investigate the effects of occupational silica exposure on oxidative stress parameters including the activities of superoxide dismutase (SOD), catalase (CAT), glutathione reductase (GR), glutathione peroxidase (GPx), and levels of total glutathione (GSH) and thiobarbituric acid reactive substance (TBARS) as well as immune system parameters such as interleukin (IL)-1α, IL-1β, IL-2, IL-4, IL-6, and IL-10 and tumor necrosis factor (TNF)-α in Turkish ceramic workers. In this study, nearly 50% of Turkish ceramic workers were diagnosed with silicosis. Eighty-four percent of these silicotic workers were found to present with profusion category 1 silicosis, whereas controls (n = 81) all displayed normal chest radiographs. Data demonstrated a significant decrease in levels of GSH and activities of CAT, SOD, and GPx, but a significant increase in MDA levels and activity of GR in all workers. Further, workers possessed significantly higher levels of IL-1α, IL-1β, IL-2, IL-4, IL-6, IL-10, and TNF-α. These observations suggest that ceramic workers may have impaired antioxidant/oxidant status and activated immune system indicative of inflammatory responses.
硅是仅次于氧的第二常见元素，因此，在多种职业中都会接触到结晶硅粉尘，如金属铸造厂、建筑行业以及陶瓷、采石和陶器行业。由于接触结晶硅与矽肺、肺癌和其他肺部疾病有关，这种元素造成的不良影响已成为全球关注的问题。工人接触硅粉尘仍然被认为是一个重要的健康问题，尤其是在发展中国家。本研究的目的是调查职业性接触硅对氧化应激参数的影响，这些参数包括超氧化物歧化酶（SOD）、过氧化氢酶（CAT）、谷胱甘肽还原酶（GR）、谷胱甘肽过氧化物酶（GPx）的活性，以及总谷胱甘肽（GSH）和硫代巴比妥酸反应物质（TBARS）的水平，还有免疫系统参数，如白细胞介素（IL）-1α、IL-1β、IL-2、IL-4、IL-6和IL-10以及肿瘤坏死因子（TNF）-α，研究对象为土耳其陶瓷工人。在本研究中，近50%的土耳其陶瓷工人被诊断患有矽肺。这些矽肺工人中有84%被发现患有1级矽肺，而对照组（n = 81）的胸部X光片均显示正常。数据表明，所有工人的GSH水平以及CAT、SOD和GPx的活性均显著降低，但丙二醛（MDA）水平和GR的活性显著升高。此外，工人体内IL-1α、IL-1β、IL-2、IL-4、IL-6、IL-10和TNF-α的水平明显更高。这些观察结果表明，陶瓷工人可能存在抗氧化/氧化状态受损以及免疫系统激活的情况，这表明存在炎症反应。
