Lai Chun-Lin, Xing Jin-Ping, Liu Xiao-Hong, Qi Jie, Zhao Jian-Qiang, Ji You-Rui, Yang Wu-Xiao, Yan Pu-Juan, Luo Chun-Yan, Ruan Lu-Fang
Department of Cardiology, Shanxi Provincial People's Hospital, Taiyuan, Shanxi 030012, China.
Postgraduate School of Shanxi Medical University, Taiyuan, Shanxi 030012, China.
Chin Med J (Engl). 2017 Jun 5;130(11):1296-1302. doi: 10.4103/0366-6999.206343.
Atherosclerosis (AS) is an inflammatory disease. Inflammation was considered to play a role in the whole process of AS. This study aimed to analyze the relationships of inflammatory factors and risk factors with different target organ damages (TOD) in essential hypertension (EH) patients and to explore its clinical significance.
A total of 294 EH patients were selected and divided into four groups according to their conditions of TOD. Forty-eight healthy subjects were selected as control. The clinical biochemical parameters, serum amyloid A, serum tryptase, and lipoprotein-associated phospholipase A2 (Lp-PLA2) in each group were detected, and the related risk factors were also statistically analyzed.
Fibrinogen (Fbg) was the most significant independent risk factor in acute coronary syndrome (ACS) group (odds ratio [OR]: 22.242, 95% confidence interval [CI]: 6.458-76.609, P< 0.001) with the largest absolute value of the standardized partial regression coefficient B' (b': 1.079). Lp-PLA2 was the most significant independent risk factor in stroke group (OR: 13.699, 95% CI: 5.236-35.837, P< 0.001) with b' = 0.708. Uric acid (UA) was the most significant independent risk factor in renal damage group (OR: 15.307, 95% CI: 4.022-58.250, P< 0.001) with b' = 1.026.
Fbg, Lp-PLA2, and UA are the strongest independent risk factors toward the occurrence of ACS, ischemic stroke, and renal damage in EH patients, thus exhibiting the greatest impacts on the occurrence of ACS, ischemic stroke, and renal damage in EH patients, respectively.
动脉粥样硬化（AS）是一种炎症性疾病。炎症被认为在AS的整个过程中发挥作用。本研究旨在分析炎症因子和危险因素与原发性高血压（EH）患者不同靶器官损害（TOD）的关系，并探讨其临床意义。
选取294例EH患者，根据其TOD情况分为四组。选取48例健康受试者作为对照。检测每组患者的临床生化参数、血清淀粉样蛋白A、血清类胰蛋白酶和脂蛋白相关磷脂酶A2（Lp-PLA2），并对相关危险因素进行统计学分析。
纤维蛋白原（Fbg）是急性冠状动脉综合征（ACS）组中最显著的独立危险因素（比值比[OR]：22.242，95%置信区间[CI]：6.458 - 76.609，P < 0.001），标准化偏回归系数B'的绝对值最大（b'：1.079）。Lp-PLA2是卒中组中最显著的独立危险因素（OR：13.699，95%CI：5.236 - 35.837，P < 0.001），b' = 0.708。尿酸（UA）是肾损害组中最显著的独立危险因素（OR：15.307，95%CI：4.022 - 58.250，P < 0.001），b' = 1.026。
Fbg、Lp-PLA2和UA分别是EH患者发生ACS、缺血性卒中和肾损害的最强独立危险因素，因此分别对EH患者发生ACS、缺血性卒中和肾损害的影响最大。
