Frontier Research Institute for Interdisciplinary Sciences (FRIS), Tohoku University, Sendai 980-8578, Japan.
Laboratory for Histogenetic Dynamics, Graduate School of Life Sciences, Tohoku University, Sendai 980-8578, Japan.
Cell Death Differ. 2017 Aug;24(8):1422-1430. doi: 10.1038/cdd.2017.36. Epub 2017 May 19.
Caspases are at the core of executing apoptosis by orchestrating cellular destruction with proteolytic cascades. Caspase-mediated proteolysis also controls diverse nonlethal cellular activities such as proliferation, differentiation, cell fate decision, and cytoskeletal reorganization. During the last decade or so, genetic studies of Drosophila have contributed to our understanding of the in vivo mechanism of the non-apoptotic cellular responses in developmental contexts. Furthermore, recent studies using C. elegans suggest that apoptotic signaling may play unexpected roles, which influence ageing and normal development at the organism level. In this review, we describe how the caspase activity is elaborately controlled during vital cellular processes at the level of subcellular localization, the duration and timing to avoid full apoptotic consequences, and also discuss the novel roles of non-apoptotic caspase signaling in adult homeostasis and physiology.
Caspases 是执行细胞凋亡的核心，通过蛋白酶级联反应来协调细胞的破坏。Caspase 介导的蛋白水解还控制着多种非致死性细胞活动，如增殖、分化、细胞命运决定和细胞骨架重组。在过去的十年左右，果蝇的遗传研究有助于我们理解发育背景下非凋亡性细胞反应的体内机制。此外，最近使用秀丽隐杆线虫的研究表明，凋亡信号可能发挥意想不到的作用，这些作用会影响生物体水平的衰老和正常发育。在这篇综述中，我们描述了 caspase 活性如何在细胞水平的亚细胞定位、持续时间和时间安排上进行精细控制，以避免完全的凋亡后果，还讨论了非凋亡性 caspase 信号在成体稳态和生理学中的新作用。
