广而告之：细胞凋亡在发育、再生和疾病过程中的非自主效应
Spreading the word: non-autonomous effects of apoptosis during development, regeneration and disease.
作者信息
Pérez-Garijo Ainhoa, Steller Hermann
机构信息
Strang Laboratory of Apoptosis and Cancer Biology, Howard Hughes Medical Institute, The Rockefeller University, New York, NY 10065, USA.
Strang Laboratory of Apoptosis and Cancer Biology, Howard Hughes Medical Institute, The Rockefeller University, New York, NY 10065, USA
出版信息
Development. 2015 Oct 1;142(19):3253-62. doi: 10.1242/dev.127878.
Apoptosis, in contrast to other forms of cell death such as necrosis, was originally regarded as a 'silent' mechanism of cell elimination designed to degrade the contents of doomed cells. However, during the past decade it has become clear that apoptotic cells can produce diverse signals that have a profound impact on neighboring cells and tissues. For example, apoptotic cells can release factors that influence the proliferation and survival of adjacent tissues. Apoptosis can also affect tissue movement and morphogenesis by modifying tissue tension in surrounding cells. As we review here, these findings reveal unexpected roles for apoptosis in tissue remodeling during development, as well as in regeneration and cancer.
与坏死等其他形式的细胞死亡不同，细胞凋亡最初被视为一种“沉默”的细胞清除机制，旨在降解注定要死亡的细胞内容物。然而，在过去十年中，越来越清楚的是，凋亡细胞可以产生各种信号，对邻近细胞和组织产生深远影响。例如，凋亡细胞可以释放影响相邻组织增殖和存活的因子。细胞凋亡还可以通过改变周围细胞的组织张力来影响组织运动和形态发生。正如我们在此所综述的，这些发现揭示了细胞凋亡在发育过程中的组织重塑以及再生和癌症中的意外作用。
Zotero 插件