急性给予乙醇和乙醛对大鼠大脑中的L型钙通道产生相似的影响。

Acute ethanol and acetaldehyde administration produce similar effects on L-type calcium channels in rat brain.

作者信息

Bergamaschi S, Govoni S, Rius R A, Trabucchi M

机构信息

Institute of Pharmacological Sciences, University of Milan, Italy.

出版信息

Alcohol. 1988 Jul-Aug;5(4):337-40. doi: 10.1016/0741-8329(88)90076-6.

DOI:10.1016/0741-8329(88)90076-6

PMID:2852497

Abstract

The present study investigates the effect of acute ethanol and acetaldehyde administration on neuronal L-type calcium channels by measuring the binding of 3H-nitrendipine (3H-NTP). Acute ethanol (3 g/kg orally) transiently increases (+40% at 40 min) 3H-NTP binding. Acetaldehyde has a similar effect, but the onset of action is shorter; in fact the binding increase peaks 15 min following administration and is completely reversible within 2 hours. Disulfiram pretreatment does not modify the effect produced by acute ethanol on 3H-NTP binding. The results indicate that acetaldehyde may participate in mediating the action of ethanol on voltage sensitive L-type calcium channels with consequent alterations of neuronal excitability.

摘要

本研究通过测量³H-尼群地平（³H-NTP）的结合情况，探讨急性给予乙醇和乙醛对神经元L型钙通道的影响。急性给予乙醇（口服3 g/kg）可使³H-NTP结合短暂增加（40分钟时增加40%）。乙醛有类似作用，但起效时间较短；实际上，给药后15分钟结合增加达到峰值，2小时内完全可逆。双硫仑预处理不改变急性乙醇对³H-NTP结合产生的作用。结果表明，乙醛可能参与介导乙醇对电压敏感性L型钙通道的作用，从而改变神经元兴奋性。