甲硫氨酸脑啡肽和脑啡肽类似物FK-33824可中枢性抑制绵羊促肾上腺皮质激素的分泌。

Met-enkephalin and the enkephalin analogue FK-33824 centrally inhibit adrenocorticotrophic hormone secretion in sheep.

Wang X M, Tresham J J, Scoggins B A, Coghlan J P

Howard Florey Institute of Experimental Physiology and Medicine, University of Melbourne, Parkville, Victoria, Australia.

Clin Exp Pharmacol Physiol. 1988 Nov;15(11):865-73. doi: 10.1111/j.1440-1681.1988.tb01029.x.

Abstract

The effects of central administration of met-enkephalin, leu-enkephalin, the enkephalin analogue FK-33824 and the opiate antagonist naloxone on plasma concentration of adrenocorticotrophic hormone (ACTH) were examined in conscious sheep. 2. Intracerebroventricular infusion of met-enkephalin and FK-33824 significantly decreased the basal plasma concentration of ACTH. 3. Intracerebroventricular infusion of FK-33824 inhibited the haemorrhage-induced increase in plasma concentration of ACTH. 4. Intracerebroventricular infusion of naloxone attenuated the central inhibition of plasma concentration of ACTH induced by FK-33824, but intravenous infusion of naloxone had no effect on the reduction in plasma concentration of ACTH induced by FK-33824. 5. These studies suggest that in sheep met-enkephalin may play a central inhibitory role in the control of ACTH secretion.

摘要

在清醒绵羊中研究了脑室内注射甲硫氨酸脑啡肽、亮氨酸脑啡肽、脑啡肽类似物FK - 33824和阿片拮抗剂纳洛酮对促肾上腺皮质激素（ACTH）血浆浓度的影响。2. 脑室内注射甲硫氨酸脑啡肽和FK - 33824显著降低了ACTH的基础血浆浓度。3. 脑室内注射FK - 33824抑制了出血诱导的ACTH血浆浓度升高。4. 脑室内注射纳洛酮减弱了FK - 33824对ACTH血浆浓度的中枢抑制作用，但静脉注射纳洛酮对FK - 33824诱导的ACTH血浆浓度降低没有影响。5. 这些研究表明，在绵羊中，甲硫氨酸脑啡肽可能在ACTH分泌的控制中发挥中枢抑制作用。