甲硫氨酸脑啡肽类似物FK 33 - 824和纳洛酮不会直接影响培养的人肾上腺皮质细胞的皮质醇分泌。

The met-enkephalin analog FK 33-824 and naloxone do not directly influence cortisol secretion by cultured human adrenocortical cells.

作者信息

Lamberts S W, Bons E G, Del Pozo E

出版信息

Life Sci. 1983 Feb 14;32(7):755-8. doi: 10.1016/0024-3205(83)90309-0.

Abstract

Systemic administration of the enkephalin analog FK 33.824 was previously shown to inhibit ACTH secretion in man. In this study, the direct action of this analog on cortisol release was studied. The enkephalin analog (1 microM and 10 microM) did not influence basal or ACTH-stimulated cortisol production by cultured isolated adrenocortical cells prepared from the hyperplastic adrenal glands from three patients with Cushing's disease. Naloxone (10 microM) had also no direct effect on cortisol release. It is concluded that the met-enkephalin analog used in this study and naloxone do affect the hypothalamo-pituitary-adrenal axis via a central effect.

摘要

此前研究表明，脑啡肽类似物FK 33.824的全身给药可抑制人体促肾上腺皮质激素（ACTH）的分泌。在本研究中，对该类似物对皮质醇释放的直接作用进行了研究。该脑啡肽类似物（1微摩尔和10微摩尔）对从三名库欣病患者增生的肾上腺制备的培养分离肾上腺皮质细胞的基础或促肾上腺皮质激素刺激的皮质醇生成没有影响。纳洛酮（10微摩尔）对皮质醇释放也没有直接作用。得出的结论是，本研究中使用的甲硫脑啡肽类似物和纳洛酮是通过中枢作用影响下丘脑-垂体-肾上腺轴的。