按疫苗接种状况划分的年轻成年人（18至30岁）口腔人乳头瘤病毒感染率
Prevalence of oral human papillomavirus by vaccination status among young adults (18-30years old).
作者信息
Hirth Jacqueline M, Chang Mihyun, Resto Vicente A
机构信息
Center for Interdisciplinary Research in Women's Health, Department of Obstetrics & Gynecology, University of Texas Medical Branch, United States.
Center for Interdisciplinary Research in Women's Health, University of Texas Medical Branch, United States.
出版信息
Vaccine. 2017 Jun 14;35(27):3446-3451. doi: 10.1016/j.vaccine.2017.05.025. Epub 2017 May 16.
BACKGROUND
Although there is evidence that human papillomavirus (HPV) vaccination may protect against oral HPV infection, no current research has demonstrated this in the general population.
METHODS
We used repeated cross-sectional data from the National Health and Nutrition Examination Survey (NHANES) between 2009 and 2014. Participants 18-30years who indicated whether they had received the HPV vaccine and provided an adequate oral sample were included (N=3040). Oral HPV types were grouped by vaccine-type (types 6, 11, 16, 18) and by risk (high or low risk). Chi-square analyses compared oral HPV prevalence by vaccination status.
RESULTS
Vaccinated adults had a lower prevalence of vaccine-type oral HPV (types 6, 11, 16, 18) compared to unvaccinated adults. Prevalence of non-vaccine high-risk oral HPV was similar between HPV vaccinated and unvaccinated participants.
CONCLUSIONS
HPV vaccination appears to provide protection against vaccine-type oral HPV infection among males and females in the general population.
背景
尽管有证据表明人乳头瘤病毒（HPV）疫苗接种可能预防口腔HPV感染，但目前尚无研究在普通人群中证实这一点。
方法
我们使用了2009年至2014年美国国家健康与营养检查调查（NHANES）的重复横断面数据。纳入了18至30岁、表明是否接种了HPV疫苗并提供了足够口腔样本的参与者（N = 3040）。口腔HPV类型按疫苗类型（6、11、16、18型）和风险（高风险或低风险）分组。卡方分析比较了按疫苗接种状况划分的口腔HPV患病率。
结果
与未接种疫苗的成年人相比，接种疫苗的成年人中疫苗型口腔HPV（6、11、16、18型）的患病率较低。HPV疫苗接种者和未接种者中非疫苗高风险口腔HPV的患病率相似。
结论
HPV疫苗接种似乎能为普通人群中的男性和女性预防疫苗型口腔HPV感染。
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