在澳大利亚实施全国性疫苗接种计划后，评估年轻澳大利亚女性中生殖器人乳头瘤病毒的基因型流行情况。
Assessing genital human papillomavirus genoprevalence in young Australian women following the introduction of a national vaccination program.
作者信息
Osborne Sarah L, Tabrizi Sepehr N, Brotherton Julia M L, Cornall Alyssa M, Wark John D, Wrede C David, Jayasinghe Yasmin, Gertig Dorota M, Pitts Marian K, Garland Suzanne M
机构信息
Murdoch Childrens Research Institute, Parkville, Victoria, Australia; Regional HPV Reference Laboratory, Department of Microbiology and Infectious Diseases, The Royal Women's Hospital, Parkville, Victoria, Australia.
Murdoch Childrens Research Institute, Parkville, Victoria, Australia; Regional HPV Reference Laboratory, Department of Microbiology and Infectious Diseases, The Royal Women's Hospital, Parkville, Victoria, Australia; Department of Obstetrics and Gynaecology, University of Melbourne, Parkville, Victoria, Australia.
出版信息
Vaccine. 2015 Jan 1;33(1):201-8. doi: 10.1016/j.vaccine.2014.10.045. Epub 2014 Nov 1.
OBJECTIVES
Following the implementation of Australia's National HPV Vaccination Program in April 2007, this study evaluated the prevalence of vaccine-targeted human papillomavirus (HPV) genotypes (HPV 6, 11, 16, 18) amongst vaccine-eligible young women.
METHODS
Between September 2011 and August 2013, women from Victoria, Australia aged 18-25 were recruited through targeted advertising on the social networking website Facebook. Participants completed an online questionnaire, and sexually active women were asked to provide a self-collected vaginal swab for HPV deoxyribonucleic acid (DNA) detection and genotyping. Samples positive for HPV were genotyped using the Linear Array HPV genotyping test (Roche Diagnostics). Self-reported HPV vaccination details were verified with the National HPV Vaccination Program Register (NHVPR).
RESULTS
Of 431 vaginal swabs, 24.8% were positive for HPV DNA. Vaccine-targeted HPV genotypes were detected in only seven (1.6%) samples; all HPV 16 (of the six HPV 16 positive vaccinated women, all had received the vaccine after sexual debut). There were no cases of HPV 6, 11 or 18 identified. HPV types 51, 59, 73, 84, and 89 were the most prevalent genotypes. Vaccination rates were high, with 77.3% of participants having received all three doses of the vaccine, and there was an 89.8% concordance between self-reported and registry-reported HPV vaccination status. Strong associations were observed between vaccination status, age, language spoken at home and country of birth, as well as between HPV detection and the number of male sexual partners.
CONCLUSION
Preliminary data from this study demonstrate a very low prevalence of vaccine-related HPV genotypes amongst vaccine-eligible women from Victoria, Australia. We were able to use Facebook to effectively reach and recruit young women to participate in the assessment of the impact of Australia's HPV vaccination program.
目的
2007年4月澳大利亚国家人乳头瘤病毒（HPV）疫苗接种计划实施后，本研究评估了符合疫苗接种条件的年轻女性中疫苗针对的HPV基因型（HPV 6、11、16、18）的流行情况。
方法
2011年9月至2013年8月期间，通过在社交网站Facebook上进行定向广告招募了澳大利亚维多利亚州年龄在18至25岁之间的女性。参与者完成了一份在线问卷，性活跃的女性被要求提供自行采集的阴道拭子用于HPV脱氧核糖核酸（DNA）检测和基因分型。使用线性阵列HPV基因分型检测（罗氏诊断）对HPV阳性样本进行基因分型。自我报告的HPV疫苗接种详细信息与国家HPV疫苗接种计划登记册（NHVPR）进行了核实。
结果
在431份阴道拭子中，24.8%的样本HPV DNA呈阳性。仅在7份（1.6%）样本中检测到疫苗针对的HPV基因型；所有HPV 16（在6名HPV 16阳性且已接种疫苗的女性中，所有人都在首次性行为后接种了疫苗）。未发现HPV 6、11或18的病例。HPV 51、59、73、84和89型是最常见的基因型。疫苗接种率很高，77.3%的参与者接种了全部三剂疫苗，自我报告和登记册报告的HPV疫苗接种状况之间的一致性为89.8%。在疫苗接种状况、年龄、在家中使用的语言和出生国家之间，以及HPV检测与男性性伴侣数量之间观察到了强烈的关联。
结论
本研究的初步数据表明，在澳大利亚维多利亚州符合疫苗接种条件的女性中，与疫苗相关的HPV基因型的流行率非常低。我们能够利用Facebook有效地接触和招募年轻女性参与澳大利亚HPV疫苗接种计划影响的评估。
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