Kim Do-Yeon, Kim Chang-O, Lim Hyunjung
Department of Medical Nutrition, Graduate School of East-West Medical Science, Kyung Hee University, Yongin, Republic of Korea; Research Institute of Medical Nutrition, Kyung Hee University, Seoul, Republic of Korea.
Department of Social Welfare, Seoul National University, Seoul, Republic of Korea; Clinical Research Center, Yang Ji Hospital, Seoul, Republic of Korea.
Nutrition. 2017 Jun;38:48-53. doi: 10.1016/j.nut.2016.12.023. Epub 2017 Jan 7.
The aim of this study was to assess whether diet quality and functional status were associated with serum levels of interleukin (IL)-6 and tumor necrosis factor (TNF)-α in frail, elderly, community-dwelling individuals.
Seventy-eight frail, elderly individuals (age ≥65 y, usual gait speed <0.6 m/s and Mini Nutritional Assessment <24) participated in this cross-sectional study from the National Home Healthcare Services in Gangbuk-gu, Seoul, South Korea. Diet quality was assessed using mean adequacy ratio (MAR) of the diet, which was calculated by averaging the sum of the nutrient adequacy ratios (NAR) for the intakes of energy, protein, and 11 micronutrients. Grip strength was measured as an indicator of muscle strength, and short physical performance battery (SPPB) was measured as an indicator of physical performance. The levels of the inflammatory markers IL-6 and TNF-α were obtained from serum samples.
MAR and NAR scores for phosphorus; vitamins A, B, and B; and niacin were negatively associated with IL-6 (β = -0.006, -0.004, -0.004, -0.007, -0.004, and -0.005, respectively; P < 0.05). SPPB score, as well as NAR scores for vitamin B, niacin, and vitamin C, were negatively associated with TNF-α (β = -0.098, -0.006, -0.006, and -0.004, respectively; P < 0.05).
MAR of the diet was inversely associated with IL-6 concentration in frail elderly individuals, and higher SPPB score was associated with lower levels of TNF-α. Results from the present study suggest that improving diet quality and physical performance might lower levels of inflammation in this frail, elderly population.
本研究旨在评估在体弱的社区居住老年人中，饮食质量和功能状态是否与白细胞介素（IL）-6及肿瘤坏死因子（TNF）-α的血清水平相关。
78名体弱的老年人（年龄≥65岁，日常步速<0.6米/秒且微型营养评定<24）参与了韩国首尔江北区国家家庭医疗服务中心的这项横断面研究。饮食质量采用饮食平均充足率（MAR）进行评估，MAR通过计算能量、蛋白质及11种微量营养素摄入量的营养素充足率（NAR）之和的平均值得出。握力作为肌肉力量的指标进行测量，简短体能状况量表（SPPB）作为身体机能的指标进行测量。炎症标志物IL-6和TNF-α的水平通过血清样本获得。
磷、维生素A、B、B族维生素及烟酸的MAR和NAR评分与IL-6呈负相关（β分别为-0.006、-0.004、-0.004、-0.007、-0.004和-0.005；P<0.05）。SPPB评分以及维生素B、烟酸和维生素C的NAR评分与TNF-α呈负相关（β分别为-0.098、-0.006、-0.006和-0.004；P<0.05）。
体弱老年人的饮食MAR与IL-6浓度呈负相关，较高的SPPB评分与较低的TNF-α水平相关。本研究结果表明，改善饮食质量和身体机能可能会降低该体弱老年人群的炎症水平。
