光动力疗法治疗外阴硬化性苔藓。

Photodynamic therapy in the treatment of vulvar lichen sclerosus.

机构信息

Department of Gynecologic Oncology, The Maria Sklodowska-Curie Memorial Cancer Centre and Institute of Oncology in Warsaw, Roentgena Street 5, 02-781 Warsaw, Poland.

出版信息

Photodiagnosis Photodyn Ther. 2017 Sep;19:135-139. doi: 10.1016/j.pdpdt.2017.05.011. Epub 2017 May 17.

DOI:10.1016/j.pdpdt.2017.05.011

PMID:28526592

Abstract

BACKGROUND

Vulvar lichen sclerosus is a chronic and incurable disease that causes various unpleasant symptoms and serious consequences.

OBJECTIVE

The purpose of the study was to assess the effectiveness of photodynamic therapy in the treatment of vulvar lichen sclerosus.

METHODS

Participants in the study included 102 female patients aged 19-85 suffer from vulvar lichen sclerosus. The patients underwent photodynamic therapy (PDT). In the course of PDT the 5% 5- aminolevulinic acid was used in gel form. The affected areas were irradiated with a halogenic lamp PhotoDyn 501 (590-760nm) during a 10-min radiation treatment. The treatment was repeated weekly for 10 weeks.

RESULT

PDT has brought about a good therapeutic effect (complete or partial clinical remission), with 87.25% improvement rate in patients suffering from lichen sclerosus. The greatest vulvoscopic response was observed in the reduction of subepithelial ecchymoses and teleangiectasia (78.95%), and the reduction of erosions and fissures (70.97%). A partial remission of lichenification with hyperkeratosis was observed in 51.61% of cases. The least response was observed in the atrophic lesions reduction (improvement in 37.36% of cases).

CONCLUSION

Our patients suffering from vulvar lichen sclerosus demonstrated positive responses to photodynamic therapy and the treatment was well tolerated. Photodynamic therapy used to treat lichen sclerosus yields excellent cosmetic results.

摘要

背景

外阴硬化性苔藓是一种慢性、不可治愈的疾病，会引起各种不适症状，并导致严重后果。

目的

本研究旨在评估光动力疗法治疗外阴硬化性苔藓的疗效。

方法

研究对象为 102 名年龄在 19-85 岁之间的女性外阴硬化性苔藓患者。患者接受光动力疗法（PDT）。在 PDT 过程中，使用 5% 5-氨基酮戊酸制成凝胶形式。在 10 分钟的辐射治疗过程中，用卤素灯 PhotoDyn 501（590-760nm）对受影响的区域进行照射。治疗每周重复一次，共进行 10 周。

结果

PDT 带来了良好的治疗效果（完全或部分临床缓解），硬化性苔藓患者的改善率为 87.25%。观察到最大的外阴镜反应是减少表皮下瘀斑和毛细血管扩张（78.95%），以及减少糜烂和皲裂（70.97%）。51.61%的病例观察到苔藓样变伴角化过度的部分缓解。萎缩性病变减少的反应最小（37.36%的病例有改善）。