Shi Lei, Miao Fei, Zhang Ling-Lin, Zhang Guo-Long, Wang Pei-Ru, Ji Jie, Wang Xiao-Jie, Huang Zheng, Wang Hong-Wei, Wang Xiu-Li
Shanghai Skin Diseases Hospital and the Institute of Photomedicine, Tongji University, Shanghai 200443, China.
Acta Derm Venereol. 2016 Jun 15;96(5):684-8. doi: 10.2340/00015555-2341.
The aim of this study was to evaluate the effectiveness of 5-aminolevulinic acid photodynamic therapy (ALA-PDT) for the treatment of vulvar lichen sclerosus (VLS) and compare its effectiveness with that of clobetasol propionate. Four sessions of topical photodynamic therapy (PDT) were administered at 2-week intervals (n = 20). Clobetasol propionate (0.05%) was used daily for 8 weeks (n = 20). The rate of complete response in the PDT group (14/20) was double that of the clobetasol propionate group (7/20) (p < 0.05, 2 = 4.912). Horizontal visual analogue scores indicated that PDT was more effective than clobetasol propionate. Pain intensity numeric rating scale values for PDT were between 3.05 and 4.45. One month after the final session of PDT, only one patient relapsed and all 7 patients in clobetasol propionate group relapsed. ALA-PDT is a well-tolerated and effective option for the treatment of VLS.
本研究旨在评估5-氨基酮戊酸光动力疗法（ALA-PDT）治疗外阴硬化性苔藓（VLS）的有效性，并将其有效性与丙酸氯倍他索进行比较。以2周的间隔进行4次局部光动力疗法（PDT）（n = 20）。每天使用0.05%的丙酸氯倍他索，持续8周（n = 20）。PDT组的完全缓解率（14/20）是丙酸氯倍他索组（7/20）的两倍（p < 0.05，χ² = 4.912）。水平视觉模拟评分表明PDT比丙酸氯倍他索更有效。PDT的疼痛强度数字评定量表值在3.05至4.45之间。在PDT最后一次治疗后1个月，只有1例患者复发，而丙酸氯倍他索组的所有7例患者均复发。ALA-PDT是一种耐受性良好且有效的VLS治疗选择。
