Sasajima K, Hayashi N, Yamashita K, Onda M, Takubo K
First Department of Surgery, Nippon Medical School, Tokyo, Japan.
J Clin Gastroenterol. 1988 Dec;10(6):667-71. doi: 10.1097/00004836-198812000-00020.
We report an esophageal oat cell carcinoma with multiple differentiation in a 75-year-old man who had a flat lesion with nodular projections in the middle third of the esophagus. Most of the resected tumor consisted of small round cells that contained neurosecretory granules, tonofilaments, and desmosomes. The tumor cells invaded only into the submucosa with extensive intraepithelial spreading. Foci of adenoid cystic, glandular, and squamous differentiation were found in some areas, and had continuity with the intraepithelial spreading carcinoma. Transition was also found. These findings suggest that the small cells had a propensity to undergo further adenoid cystic, glandular, and squamous differentiation.
我们报告一例75岁男性的食管燕麦细胞癌，具有多种分化，该患者食管中1/3处有一伴有结节状隆起的扁平病变。大部分切除的肿瘤由含有神经分泌颗粒、张力丝和桥粒的小圆形细胞组成。肿瘤细胞仅侵犯至黏膜下层，并伴有广泛的上皮内播散。在一些区域发现腺样囊性、腺性和鳞状分化灶，且与上皮内播散癌相连。还发现了过渡区。这些发现提示小细胞有进一步向腺样囊性、腺性和鳞状分化的倾向。
