Franchi Silvia, Sacerdote Paola, Panerai Alberto
Dipartimento di Scienze Farmacologiche e Biomolecolari, Università degli Studi Milano, Milan, Italy.
Neurol Sci. 2017 May;38(Suppl 1):27-30. doi: 10.1007/s10072-017-2875-z.
Prokineticins (PK) 1 and 2 belong to a new family of chemokines capable to interact with two different G coupled receptors: Prokineticin receptor (PKR)1 and 2. Both prokineticins and their receptors are widely distributed in different tissues and regulate several biological functions. In particular, a role of the PK system in inflammation and nociception has been established. PKRs are expressed in regions of the nervous system associated with pain and in primary sensitive neurons they colocalize with transient potential receptor vanilloid-TRPV1 providing an anatomical interaction in nociceptor sensitization. Moreover, PKs are strongly upregulated in immune and glial cells and sustain a proinflammatory loop in inflamed tissues. Recent evidences indicate that the block of the PK system represents a promising strategy to contrast inflammation and pain.
促动力蛋白（PK）1和2属于一类新的趋化因子家族，能够与两种不同的G蛋白偶联受体相互作用：促动力蛋白受体（PKR）1和2。促动力蛋白及其受体广泛分布于不同组织中，并调节多种生物学功能。特别是，PK系统在炎症和痛觉中的作用已经确立。PKR在与疼痛相关的神经系统区域表达，在初级感觉神经元中，它们与瞬时电位香草酸受体1（TRPV1）共定位，在伤害感受器敏化中提供解剖学上的相互作用。此外，PK在免疫细胞和神经胶质细胞中强烈上调，并在炎症组织中维持促炎循环。最近的证据表明，阻断PK系统是对抗炎症和疼痛的一种有前景的策略。
