Wagner Kayla E, Kates Wendy R, Fremont Wanda, Antshel Kevin M
Department of Psychology, Syracuse University, 430 Huntington Hall Syracuse, Syracuse, NY, 13244, USA.
Department of Psychiatry and Behavioral Sciences, SUNY-Upstate Medical University, Syracuse, NY, USA.
J Autism Dev Disord. 2017 Aug;47(8):2480-2501. doi: 10.1007/s10803-017-3165-6.
The primary objectives of the current prospective longitudinal study were to (a) describe social functioning outcomes and (b) identify childhood predictors of social functioning in young adults with 22q11.2 deletion syndrome (22q11.2DS). Childhood predictors of young adult social functioning were examined. Family environment and parental stress in adolescence were investigated as potential mediators between childhood variables and adult social functioning. Parent rated childhood internalizing symptoms significantly predicted young adult social functioning in 22q11.2DS, even after controlling for concurrent positive symptoms of psychosis, and problem behaviors contributing to parenting stress in adolescence partially mediated this relationship. These findings highlight child internalizing symptoms and adolescent problem behaviors as potential targets for social functioning interventions in 22q11.2DS.
(a) 描述社交功能结果；(b) 确定患有22q11.2缺失综合征（22q11.2DS）的年轻成年人社交功能的童年预测因素。对年轻成年人社交功能的童年预测因素进行了研究。研究了青少年时期的家庭环境和父母压力，将其作为童年变量与成人社交功能之间的潜在中介因素。即使在控制了同时出现的精神病阳性症状之后，父母评定的童年内化症状仍能显著预测22q11.2DS患者的年轻成年人社交功能，而导致青少年养育压力的问题行为部分介导了这种关系。这些发现突出了儿童内化症状和青少年问题行为，作为22q11.2DS社交功能干预的潜在目标。
