Silva Ana Luísa, Ourique Carolina, Martins Filipe, Friões Fernando
Serviço de Medicina Interna. Centro Hospitalar de São João. Porto. Portugal.
Unidade de Cuidados Intermédios de Medicina. Centro Hospitalar de São João. Porto. Portugal.
Acta Med Port. 2017 Feb 27;30(2):151-153. doi: 10.20344/amp.7907.
Lithium has a narrow therapeutic window. Frequent monitoring of both serum levels and clinical signs of toxicity is warranted because toxicity may be present even when concentrations are within the therapeutic range. We report the case of a man with lithium poisoning, with persistent neurologic signs and symptoms even after removal of lithium from circulation - a diagnosis of syndrome of irreversible lithium-effectuated neurotoxicity (SILENT) was made.
锂的治疗窗很窄。由于即使浓度在治疗范围内也可能出现毒性，因此有必要经常监测血清水平和毒性的临床体征。我们报告了一例锂中毒病例，即使锂从循环中清除后，患者仍有持续的神经体征和症状——最终诊断为不可逆性锂所致神经毒性综合征（SILENT）。
