Dolan Samantha B, MacNeil Adam
Global Immunization Division, Center for Global Health, Centers for Disease Control and Prevention, United States.
Global Immunization Division, Center for Global Health, Centers for Disease Control and Prevention, United States.
Vaccine. 2017 Jun 14;35(27):3441-3445. doi: 10.1016/j.vaccine.2017.05.026. Epub 2017 May 17.
Third dose diphtheria tetanus pertussis (DTP3) administrative coverage is a commonly used indicator for immunization program performance, although studies have demonstrated data quality issues with administrative DTP3 coverage. It is possible that administrative coverage for DTP3 may be inflated more than for other antigens. To examine this, theory, we compiled immunization coverage estimates from recent country surveys (n=71) and paired these with corresponding administrative coverage estimates, by country and cohort year, for DTP3 and 4 other antigens. Median administrative coverage was higher than survey estimates of coverage for all antigens (median differences from 26 to 30%), however this difference was similar for DTP3 as for all other antigens. These findings were consistent when countries were stratified by income level and eligibility for Gavi funding. Our findings demonstrate that while country administrative coverage estimates tend to be higher than survey estimates, DTP3 administrative coverage is not inflated more than other antigens.
第三剂白喉破伤风百日咳（DTP3）疫苗接种覆盖率是衡量免疫规划绩效的常用指标，尽管研究表明行政记录的DTP3覆盖率存在数据质量问题。DTP3的行政覆盖率可能比其他抗原的行政覆盖率夸大得更多。为了从理论上检验这一点，我们汇总了近期各国调查（n = 71）中的免疫接种覆盖率估计值，并按国家和队列年份将这些估计值与DTP3及其他4种抗原相应的行政覆盖率估计值进行配对。行政覆盖率中位数高于所有抗原的调查覆盖率估计值（中位数差异为26%至30%），然而DTP3的这一差异与所有其他抗原的差异相似。当按收入水平和获得全球疫苗免疫联盟（Gavi）资助的资格对国家进行分层时，这些结果是一致的。我们的研究结果表明，虽然各国行政覆盖率估计值往往高于调查估计值，但DTP3的行政覆盖率并不比其他抗原夸大得更多。
