Barker Thomas H, Engler Adam J
Department of Biomedical Engineering, School of Engineering and Applied Sciences and School of Medicine, University of Virginia, Charlottesville, VA.
Department of Bioengineering, Jacob School of Engineering, University of California San Diego, La Jolla, CA.
Matrix Biol. 2017 Jul;60-61:1-4. doi: 10.1016/j.matbio.2017.04.003.
Since its conceptualization in the 1980s, the provisional matrix has often been characterized as a simple fibrin-containing scaffold for wound healing that supports the nascent blood clot and is functionally distinct from the basement membrane. However subsequent advances have shown that this matrix is far from passive, with distinct compositional differences as the wound matures, and providing an active role for wound remodeling. Here we review the stages of this matrix, provide an update on the state of our understanding of provisional matrix, and present some of the outstanding issues related to the provisional matrix, its components, and their assembly and use in vivo.
自20世纪80年代被提出概念以来，临时基质通常被描述为一种简单的含纤维蛋白的伤口愈合支架，它支撑新生的血凝块，在功能上与基底膜不同。然而，随后的研究进展表明，这种基质远非被动的，随着伤口成熟，其组成存在明显差异，并在伤口重塑中发挥积极作用。在这里，我们回顾了这种基质的各个阶段，更新了我们对临时基质的理解状态，并提出了一些与临时基质、其成分以及它们在体内的组装和用途相关的突出问题。
