Liu Zhengyuan, Xu Junnan, Wang Xing
Beijing National Laboratory for Molecular Sciences Institute of Chemistry Chinese Academy of Sciences Beijing China.
Sino-Danish College University of Chinese Academy of Sciences (UCAS) Beijing China.
MedComm (2020). 2025 Mar 22;6(4):e70113. doi: 10.1002/mco2.70113. eCollection 2025 Apr.
Wound healing remains a critical global healthcare challenge, with an annual treatment cost exceeding $50 billion worldwide. Over the past decade, significant advances in wound care have focused on developing sophisticated biomaterials that promote tissue regeneration and prevent complications. Despite these developments, there remains a crucial need for multifunctional wound healing materials that can effectively address the complex, multiphase nature of wound repair while being cost effective and easily applicable in various clinical settings. This review systematically analyzes the latest developments in wound healing materials, examining their chemical composition, structural design, and therapeutic mechanisms. We comprehensively evaluate various bioactive components, including natural polymers, synthetic matrices, and hybrid composites, along with their different forms, such as hydrogels, powders, and smart dressings. Special attention is given to emerging strategies in material design that integrate multiple therapeutic functions, including sustained drug delivery, infection prevention, and tissue regeneration promotion. The insights provided in this review illuminate the path toward next-generation wound healing materials, highlighting opportunities for developing more effective therapeutic solutions that can significantly improve patient outcomes and reduce healthcare burden.
伤口愈合仍然是一项严峻的全球医疗挑战，全球每年的治疗费用超过500亿美元。在过去十年中，伤口护理取得的重大进展主要集中在开发促进组织再生和预防并发症的先进生物材料上。尽管有这些进展，但仍然迫切需要多功能伤口愈合材料，这种材料能够有效应对伤口修复复杂的多阶段性质，同时具有成本效益且易于应用于各种临床环境。本综述系统地分析了伤口愈合材料的最新进展，研究了它们的化学成分、结构设计和治疗机制。我们全面评估了各种生物活性成分，包括天然聚合物、合成基质和混合复合材料，以及它们的不同形式，如水凝胶、粉末和智能敷料。特别关注材料设计中的新兴策略，这些策略整合了多种治疗功能，包括持续药物递送、预防感染和促进组织再生。本综述提供的见解为下一代伤口愈合材料指明了方向，突出了开发更有效治疗方案的机会，这些方案可以显著改善患者预后并减轻医疗负担。
