Hakiri Shuhei, Kawaguchi Koji, Fukui Takayuki, Fukumoto Koichi, Nakamura Shota, Yokoi Kohei
Department of Thoracic Surgery, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Department of Thoracic Surgery, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Ann Thorac Surg. 2017 Jun;103(6):e525-e527. doi: 10.1016/j.athoracsur.2016.11.067.
We report a rare case of mediastinal nonseminomatous germ cell tumor arising after 2 complete resections of mediastinal mature teratomas 18 and 10 years prior. After three cycles of chemotherapy for the mediastinal nonseminomatous germ cell tumor, the serum α-fetoprotein and β-human chorionic gonadotropin levels were normalized. However, chest radiography revealed that the mediastinal tumor had remarkably increased in size, and thus growing teratoma syndrome was diagnosed. The patient underwent urgent resection of the tumor, and a pathologic examination showed an encapsulated mature teratoma without any malignant viable cells. The patient was well without disease 54 months after the third operation.
我们报告了一例罕见的纵隔非精原细胞瘤性生殖细胞肿瘤病例，该肿瘤发生于18年前和10年前两次完整切除纵隔成熟畸胎瘤之后。针对纵隔非精原细胞瘤性生殖细胞肿瘤进行三个周期的化疗后，血清甲胎蛋白和β-人绒毛膜促性腺激素水平恢复正常。然而，胸部X线检查显示纵隔肿瘤大小显著增加，因此诊断为生长中的畸胎瘤综合征。患者接受了肿瘤紧急切除术，病理检查显示为包膜完整的成熟畸胎瘤，无任何恶性活细胞。第三次手术后54个月，患者情况良好，无疾病复发。
