Department of Psychiatry, Taipei Veterans General Hospital, Taipei, Taiwan; Department of Psychiatry, College of Medicine, National Yang-Ming University, Taipei, Taiwan.
Department of Psychiatry, Taipei Veterans General Hospital, Taipei, Taiwan.
J Affect Disord. 2017 Sep;219:80-85. doi: 10.1016/j.jad.2017.05.005. Epub 2017 May 8.
Previous studies suggested that patients with borderline personality disorder (BPD) had a higher prevalence of stroke-related risk factors, such as hypertension, dyslipidemia, and diabetes mellitus. But, the association between BPD and subsequent stroke has been rarely investigated.
Using the Taiwan National Health Insurance Research Database, 5969 borderline patients aged 18 years and older and 23,876 age-and sex-matched controls were enrolled between 2002 and 2009, and followed up to the end of 2011 to identify the development of stroke.
The Cox regression model after adjusting for demographic data, psychiatric comorbidities, and medical comorbidities showed that BPD was associated with an increased risk of developing any stroke (HR: 4.82, 95% CI: 2.77-8.40) and ischemic stroke (HR: 5.67, 95% CI: 2.49-12.93). The findings of sensitivity analysis after excluding the first year of observation were consistent: any stroke (HR: 3.44, 95% CI: 1.83-6.47) and ischemic stroke (HR: 4.75, 95% CI: 1.91-11.77).
Patients with BPD had an elevated vulnerability to subsequent stroke and ischemic stroke compared to those without BPD. Further studies would be required to investigate the underlying mechanisms.
先前的研究表明，边缘型人格障碍（BPD）患者中风相关的风险因素如高血压、血脂异常和糖尿病的患病率较高。但是，BPD 与随后的中风之间的关联很少被研究。
使用台湾全民健康保险研究数据库，2002 年至 2009 年间纳入了 5969 名年龄在 18 岁及以上的边缘型患者和 23876 名年龄和性别匹配的对照者，并随访至 2011 年底，以确定中风的发生情况。
调整人口统计学数据、精神共病和合并症后，Cox 回归模型显示 BPD 与发展为任何类型中风（HR：4.82，95%CI：2.77-8.40）和缺血性中风（HR：5.67，95%CI：2.49-12.93）的风险增加相关。排除观察的第一年的敏感性分析结果一致：任何类型中风（HR：3.44，95%CI：1.83-6.47）和缺血性中风（HR：4.75，95%CI：1.91-11.77）。
与没有 BPD 的患者相比，BPD 患者发生后续中风和缺血性中风的风险增加。需要进一步研究来探讨潜在的机制。
