Endocrinology and Diabetes Research Unit, Schneider Children's Medical Center, Israel.
Endocrinology and Diabetes Research Unit, Schneider Children's Medical Center, Israel.
Mutat Res Rev Mutat Res. 2017 Apr-Jun;772:123-133. doi: 10.1016/j.mrrev.2016.08.002. Epub 2016 Aug 5.
Laron syndrome (LS) is a unique model of congenital IGF-I deficiency. It is characterized by dwarfism and obesity, and is caused by deletion or mutations of the growth hormone receptor (GH-R) gene. It is hypothesized that LS is an old disease originating in Indonesia and that the mutated gene spread to South Asia, the Middle East, the Mediterranean region and South America.
拉隆综合征（LS）是一种独特的先天性 IGF-1 缺乏症模型。其特征为侏儒症和肥胖症，由生长激素受体（GH-R）基因突变或缺失引起。据推测，LS 是一种起源于印度尼西亚的古老疾病，其突变基因传播到南亚、中东、地中海地区和南美洲。
