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Key targets for small molecule drugs on the IGF1 signaling pathway.

作者信息

Werner Haim

机构信息

Department of Human Molecular Genetics and Biochemistry, Faculty of Medical and Health Sciences, Tel Aviv University, Tel Aviv, Israel.

出版信息

Future Med Chem. 2025 Apr;17(7):751-753. doi: 10.1080/17568919.2025.2470105. Epub 2025 Feb 20.

DOI:10.1080/17568919.2025.2470105
PMID:39980245
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12026114/
Abstract
摘要

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本文引用的文献

1
The IGF1 Signaling Pathway: From Basic Concepts to Therapeutic Opportunities.IGF1 信号通路：从基础概念到治疗机会。
Int J Mol Sci. 2023 Oct 4;24(19):14882. doi: 10.3390/ijms241914882.
2
Hallmarks of cancer: The insulin-like growth factors perspective.癌症的特征：胰岛素样生长因子视角
Front Oncol. 2022 Nov 21;12:1055589. doi: 10.3389/fonc.2022.1055589. eCollection 2022.
3
Editorial: The Role of the IGF/Insulin-IGFBP Axis in Normal Physiology and Disease.社论：胰岛素样生长因子/胰岛素-胰岛素样生长因子结合蛋白轴在正常生理和疾病中的作用
Front Endocrinol (Lausanne). 2022 Apr 21;13:892140. doi: 10.3389/fendo.2022.892140. eCollection 2022.
4
Investigational IGF1R inhibitors in early stage clinical trials for cancer therapy.在癌症治疗的早期临床试验中，研究性 IGF1R 抑制剂。
Expert Opin Investig Drugs. 2019 Dec;28(12):1101-1112. doi: 10.1080/13543784.2019.1694660. Epub 2019 Nov 23.
5
Therapeutic Targeting of the IGF Axis.IGF 轴的治疗靶向。
Cells. 2019 Aug 14;8(8):895. doi: 10.3390/cells8080895.
6
IGF-I deficiency, longevity and cancer protection of patients with Laron syndrome.IGF-I 缺乏症、拉隆综合征患者的长寿和癌症保护。
Mutat Res Rev Mutat Res. 2017 Apr-Jun;772:123-133. doi: 10.1016/j.mrrev.2016.08.002. Epub 2016 Aug 5.
7
Identification of signaling pathways associated with cancer protection in Laron syndrome.拉伦综合征中与癌症保护相关的信号通路的鉴定。
Endocr Relat Cancer. 2016 May;23(5):399-410. doi: 10.1530/ERC-16-0054. Epub 2016 Apr 18.
8
Phase I Dose-Escalation Study of Linsitinib (OSI-906) and Erlotinib in Patients with Advanced Solid Tumors.林西替尼（OSI-906）与厄洛替尼联合用于晚期实体瘤患者的I期剂量递增研究。
Clin Cancer Res. 2016 Jun 15;22(12):2897-907. doi: 10.1158/1078-0432.CCR-15-2218. Epub 2016 Feb 1.
9
A novel oral insulin-like growth factor-1 receptor pathway modulator and its implications for patients with non-small cell lung carcinoma: A phase I clinical trial.一种新型口服胰岛素样生长因子-1受体通路调节剂及其对非小细胞肺癌患者的意义：一项I期临床试验。
Acta Oncol. 2016;55(2):140-8. doi: 10.3109/0284186X.2015.1049290. Epub 2015 Jul 10.
10
Linsitinib (OSI-906) versus placebo for patients with locally advanced or metastatic adrenocortical carcinoma: a double-blind, randomised, phase 3 study.林替司汀（OSI-906）对比安慰剂用于局部晚期或转移性肾上腺皮质癌患者：一项双盲、随机、III 期研究。
Lancet Oncol. 2015 Apr;16(4):426-35. doi: 10.1016/S1470-2045(15)70081-1. Epub 2015 Mar 18.