Osman Awad E, AlJuryyan Abdullah, Alharthi Hanan, Almoshary May
Pathology and Clinical Laboratory Management, King Fahad Medical City, Riyadh 11525, Saudi Arabia.
Pathology and Clinical Laboratory Management, King Fahad Medical City, Riyadh 11525, Saudi Arabia.
Hum Immunol. 2017 Jul-Aug;78(7-8):510-514. doi: 10.1016/j.humimm.2017.05.002. Epub 2017 May 18.
Killer immunoglobulin-like receptors (KIRs) have the ability to regulate natural killer (NK) cell function through inhibition/activation mechanisms. Healthy human cells express HLA class I ligands on their surface, which are recognized by NK cells to avoid spontaneous cell destruction. The associations of KIRs and/or HLA class 1 ligands in leukemic patients have been studied in some populations, with some of these studies demonstrating an association of specific types with leukemia. KIRs and their corresponding HLA class 1 ligands were investigated in Saudi patients with ALL and AML and compared to healthy controls. The homozygous A haplotype was found significantly more often in ALL patients ≤18years-old than in control individuals. No significant association was observed in KIRs and their corresponding HLA ligands in this study.
杀伤免疫球蛋白样受体（KIRs）能够通过抑制/激活机制调节自然杀伤（NK）细胞功能。健康人体细胞在其表面表达I类人类白细胞抗原（HLA）配体，NK细胞可识别这些配体，从而避免细胞自发破坏。在一些人群中，已经对白血病患者中KIRs和/或I类HLA配体之间的关联进行了研究，其中一些研究表明特定类型与白血病存在关联。对沙特急性淋巴细胞白血病（ALL）和急性髓细胞白血病（AML）患者的KIRs及其相应的I类HLA配体进行了研究，并与健康对照进行比较。发现纯合A单倍型在18岁及以下的ALL患者中出现的频率明显高于对照个体。在本研究中，未观察到KIRs及其相应的HLA配体之间存在显著关联。
