Agarwal Jay, Kadakia Sameep, Agaimy Abbas, Ogadzanov Anna, Khorsandi Azita, Chai Raymond L
Department of Otolaryngology - Head and Neck Surgery, New York Eye and Ear Infirmary of Mount Sinai, New York, NY, United States.
Department of Pathology, Erlangen University Hospital, Erlangen, Germany.
Am J Otolaryngol. 2017 Jul-Aug;38(4):505-507. doi: 10.1016/j.amjoto.2017.04.012. Epub 2017 Apr 22.
Pleomorphic liposarcoma (PL) is an exceedingly rare tumor of the head and neck. This aggressive liposarcoma variant portends a poorer prognosis compared to more typical sarcomatous tumors.
Multi-institutional study including two cases of PL, the first case occurring in the post-auricular region and the second in the cheek with later recurrence within the parotid bed.
Both patients were treated surgically with wide local excision. One patient required reoperation to obtain negative margins. The other patient underwent a total parotidectomy with neck dissection for recurrent intraparotid nodal disease. Both patients underwent adjuvant radiotherapy. No patient had evidence of recurrent disease with minimum one year follow-up.
Although the literature is sparse on this disease, wide surgical extirpation with negative margins and adjuvant radiation is recommended. Increased reports of this pathology can be helpful in providing practitioners with experienced-based information that can aid in early detection and treatment. We present the first case series of PL of the head and neck in the literature.
多形性脂肪肉瘤（PL）是一种极其罕见的头颈部肿瘤。与更典型的肉瘤性肿瘤相比，这种侵袭性脂肪肉瘤变体预后较差。
多机构研究，包括两例PL，第一例发生于耳后区域，第二例发生于脸颊，随后在腮腺床复发。
两名患者均接受了广泛局部切除的手术治疗。一名患者需要再次手术以获得阴性切缘。另一名患者因腮腺内淋巴结复发疾病接受了全腮腺切除术及颈部清扫术。两名患者均接受了辅助放疗。在至少一年的随访中，没有患者有疾病复发的迹象。
尽管关于这种疾病的文献较少，但建议进行切缘阴性的广泛手术切除及辅助放疗。增加这种病理情况的报告有助于为从业者提供基于经验的信息，以辅助早期检测和治疗。我们在文献中首次报道了头颈部PL的病例系列。
