Amer Kamil M, Congiusta Dominick V, Thomson Jennifer E, Elsamna Samer, Chaudhry Iftikhar, Bozzo Anthony, Amer Rami, Siracuse Brianna, Ghert Michelle, Beebe Kathleen S
Rutgers New Jersey Medical School Department of Orthopaedics, 140 Bergen Street, ACC D1610, Newark, NJ, 07103, USA.
McMaster University Division of Orthopaedic Surgery, Department of Surgery, 1280 Main Street West, Hamilton, Ontario, Canada.
J Clin Orthop Trauma. 2020 Jul;11(Suppl 4):S479-S484. doi: 10.1016/j.jcot.2020.04.013. Epub 2020 Apr 18.
Liposarcoma (LPS) is a one of the most commonly diagnosed soft tissue sarcomas. Little is known about the epidemiology and prognosis of each subtype. We present an analysis of epidemiology and survival of the subtypes of LPS using a national database.
We queried the Survival Epidemiology, and End Results (SEER) and the Canadian Institute for Clinical Evaluative Sciences (ICES) databases for data on 7 types of LPS. Pearson's chi square was used to determine associations between variables and subtypes. Kaplan-Meier and Cox Regression analyses were performed for two tests: one using SEER data and the other using variables common to both SEER and ICES.
The well-differentiated subtype was the most common subtype identified. Metastatic disease was associated with decreased survival across all subtypes and age >35 was associated with decreased survival in well-differentiated and myxoid subtypes. Tumor grade was associated with decreased survival in the well-differentiated, myxoid, mixed, and round cell subtypes. In the secondary analysis, age >35 was associated with decreased survival in the myxoid subtype.
The prognosis of liposarcoma differs greatly by subtype. Clinicians should account for patient factors at the time of diagnosis to best navigate treatment of their patients.
脂肪肉瘤（LPS）是最常被诊断出的软组织肉瘤之一。对于每种亚型的流行病学和预后了解甚少。我们使用国家数据库对LPS各亚型的流行病学和生存率进行了分析。
我们查询了生存、流行病学和最终结果（SEER）数据库以及加拿大临床评估科学研究所（ICES）数据库，以获取7种LPS的数据。使用Pearson卡方检验来确定变量与亚型之间的关联。对两项测试进行了Kaplan-Meier分析和Cox回归分析：一项使用SEER数据，另一项使用SEER和ICES共有的变量。
高分化亚型是最常见的亚型。转移疾病与所有亚型的生存率降低相关，年龄>35岁与高分化和黏液样亚型的生存率降低相关。肿瘤分级与高分化、黏液样、混合型和圆形细胞亚型的生存率降低相关。在二次分析中，年龄>35岁与黏液样亚型的生存率降低相关。
脂肪肉瘤的预后因亚型而异。临床医生在诊断时应考虑患者因素，以便为患者制定最佳治疗方案。
